Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162858
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dc.contributor.authorZhu, Houjuanen_US
dc.contributor.authorMah, Jian-Qiangen_US
dc.contributor.authorWang, Chen Gangen_US
dc.contributor.authorChan, Chui Yuen_US
dc.contributor.authorZhu, Qiangen_US
dc.contributor.authorYe, Enyien_US
dc.contributor.authorLi, Zibiaoen_US
dc.contributor.authorLoh, Xian Junen_US
dc.date.accessioned2022-11-11T03:45:08Z-
dc.date.available2022-11-11T03:45:08Z-
dc.date.issued2022-
dc.identifier.citationZhu, H., Mah, J., Wang, C. G., Chan, C. Y., Zhu, Q., Ye, E., Li, Z. & Loh, X. J. (2022). Flexible polymeric patch based nanotherapeutics against non-cancer therapy. Bioactive Materials, 18, 471-491. https://dx.doi.org/10.1016/j.bioactmat.2022.03.034en_US
dc.identifier.issn2452-199Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/162858-
dc.description.abstractFlexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance, superior biocompatibility and biodegradation, as well as high loading capability and permeability of drug. Such polymeric patches are classified into microneedles (MNs), hydrogel, microcapsule, microsphere and fiber depending on the formed morphology. The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity, promoting on-demand and regulated drug administration, thus providing the great potential to their clinic translation. In this review, the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed. The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed, including diabetes therapy, wound healing, dermatological disease therapy, bone regeneration, cardiac repair, hair repair, obesity therapy and some immune disease therapy. Alternatively, the limitations, latest challenges and future perspectives of such biomedical therapeutic devices are addressed.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.language.isoenen_US
dc.relationA2084c0168en_US
dc.relationC211718004en_US
dc.relation.ispartofBioactive Materialsen_US
dc.rights© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectEngineering::Materialsen_US
dc.titleFlexible polymeric patch based nanotherapeutics against non-cancer therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.organizationInstitute of Materials Research and Engineering, A*STARen_US
dc.identifier.doi10.1016/j.bioactmat.2022.03.034-
dc.description.versionPublished versionen_US
dc.identifier.pmid35415299-
dc.identifier.scopus2-s2.0-85127155027-
dc.identifier.volume18en_US
dc.identifier.spage471en_US
dc.identifier.epage491en_US
dc.subject.keywordsFlexible Polymeric Patchesen_US
dc.subject.keywordsMicroneedleen_US
dc.description.acknowledgementThe authors would like to acknowledge the Young Individual Research Grants (YIRG) (Grant No. A2084c0168) , Singapore and A*STAR Central Funds (Grant No. C211718004) , Singapore.en_US
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