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Title: Flexible polymeric patch based nanotherapeutics against non-cancer therapy
Authors: Zhu, Houjuan
Mah, Jian-Qiang
Wang, Chen Gang
Chan, Chui Yu
Zhu, Qiang
Ye, Enyi
Li, Zibiao
Loh, Xian Jun
Keywords: Engineering::Materials
Issue Date: 2022
Source: Zhu, H., Mah, J., Wang, C. G., Chan, C. Y., Zhu, Q., Ye, E., Li, Z. & Loh, X. J. (2022). Flexible polymeric patch based nanotherapeutics against non-cancer therapy. Bioactive Materials, 18, 471-491.
Project: A2084c0168
Journal: Bioactive Materials
Abstract: Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance, superior biocompatibility and biodegradation, as well as high loading capability and permeability of drug. Such polymeric patches are classified into microneedles (MNs), hydrogel, microcapsule, microsphere and fiber depending on the formed morphology. The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity, promoting on-demand and regulated drug administration, thus providing the great potential to their clinic translation. In this review, the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed. The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed, including diabetes therapy, wound healing, dermatological disease therapy, bone regeneration, cardiac repair, hair repair, obesity therapy and some immune disease therapy. Alternatively, the limitations, latest challenges and future perspectives of such biomedical therapeutic devices are addressed.
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2022.03.034
Schools: School of Physical and Mathematical Sciences 
Organisations: Institute of Materials Research and Engineering, A*STAR
Rights: © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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