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Title: Dual gate-controlled therapeutics for overcoming bacterium-induced drug resistance and potentiating cancer immunotherapy
Authors: Zhang, Xiaodong
Chen, Xiaokai
Guo, Yuxin
Gao, Ge
Wang, Dongdong
Wu, Yinglong
Liu, Jiawei
Liang, Gaolin
Zhao, Yanli
Wu, Fu-Gen
Keywords: Science::Chemistry
Issue Date: 2021
Source: Zhang, X., Chen, X., Guo, Y., Gao, G., Wang, D., Wu, Y., Liu, J., Liang, G., Zhao, Y. & Wu, F. (2021). Dual gate-controlled therapeutics for overcoming bacterium-induced drug resistance and potentiating cancer immunotherapy. Angewandte Chemie International Edition, 60(25), 14013-14021.
Project: A20E5c0081 
Journal: Angewandte Chemie International Edition 
Abstract: The presence of bacteria in the tumor can cause cancer resistance to chemotherapeutics. To fight against bacterium-induced drug resistance, herein we design self-traceable nanoreservoirs that are simultaneously loaded with gemcitabine (an anticancer drug) and ciprofloxacin (an antibiotic) and are decorated with hyaluronic acid for active tumor targeting. The nanoreservoirs have a pH-sensitive gate and an enzyme-responsive gate that can be opened in the acidic and hyaluronidase-abundant tumor microenvironment to control drug release rates. Moreover, the nanoreservoirs can specifically target the tumor regions without eliciting evident toxicity to normal tissues, kill the intratumoral bacteria, and inhibit the tumor growth even in the presence of the bacteria. Unexpectedly, the nanoreservoirs can activate T cell-mediated immune responses through promoting antigen-presenting dendritic cell maturation and depleting immunosuppressive myeloid-derived suppressor cells in bacterium-infected tumors.
ISSN: 1433-7851
DOI: 10.1002/anie.202102059
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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