Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/162868
Title: Inducing ring complexation for efficient capture and detection of small gaseous molecules using SERS for environmental surveillance
Authors: Nguyen, Lam Bang Thanh
Leong, Yong Xiang
Koh, Charlynn Sher Lin
Leong, Shi Xuan
Boong, Siew Kheng
Sim, Howard Yi Fan
Phan-Quang, Gia Chuong
Phang, In Yee
Ling, Xing Yi
Keywords: Engineering::Chemical technology
Issue Date: 2022
Source: Nguyen, L. B. T., Leong, Y. X., Koh, C. S. L., Leong, S. X., Boong, S. K., Sim, H. Y. F., Phan-Quang, G. C., Phang, I. Y. & Ling, X. Y. (2022). Inducing ring complexation for efficient capture and detection of small gaseous molecules using SERS for environmental surveillance. Angewandte Chemie International Edition, 61(33), e202207447-. https://dx.doi.org/10.1002/anie.202207447
Project: NRF2020NRF-CG001-010
A20E5c0082
Journal: Angewandte Chemie International Edition
Abstract: Gas-phase surface-enhanced Raman scattering (SERS) remains challenging due to poor analyte affinity to SERS substrates. The reported use of capturing probes suffers from concurrent inconsistent signals and long response time due to the formation of multiple potential probe-analyte interaction orientations. Here, we demonstrate the use of multiple non-covalent interactions for ring complexation to boost the affinity of small gas molecules, SO2 and NO2 , to our SERS platform, achieving rapid capture and multiplex detection down to 100 ppm. Experimental and in-silico studies affirm stable ring complex formation, and kinetic investigations reveal a 4-fold faster response time compared to probes without stable ring complexation capability. By synergizing spectral concatenation and support vector machine regression, we achieve 91.7 % accuracy for multiplex quantification of SO2 and NO2 in excess CO2 , mimicking real-life exhausts. Our platform shows immense potential for on-site exhaust and air quality surveillance.
URI: https://hdl.handle.net/10356/162868
ISSN: 1433-7851
DOI: 10.1002/anie.202207447
Rights: © 2022 Wiley-VCHGmbH. All rights reserved. This is the peer reviewed version of the following article: Nguyen, L. B. T., Leong, Y. X., Koh, C. S. L., Leong, S. X., Boong, S. K., Sim, H. Y. F., Phan-Quang, G. C., Phang, I. Y. & Ling, X. Y. (2022). Inducing ring complexation for efficient capture and detection of small gaseous molecules using SERS for environmental surveillance. Angewandte Chemie International Edition, 61(33), e202207447-, which has been published in final form at https://doi.org/10.1002/anie.202207447. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20230822
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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