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Title: Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH
Authors: Stsiapanava, Alena
Xu, Chenrui
Nishio, Shunsuke
Han, Ling
Yamakawa, Nao
Carroni, Marta
Tunyasuvunakool, Kathryn
Jumper, John
de Sanctis, Daniele
Wu, Bin
Jovine, Luca
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Stsiapanava, A., Xu, C., Nishio, S., Han, L., Yamakawa, N., Carroni, M., Tunyasuvunakool, K., Jumper, J., de Sanctis, D., Wu, B. & Jovine, L. (2022). Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Nature Structural & Molecular Biology, 29(3), 190-193.
Project: MOH-000382-00
Journal: Nature Structural & Molecular Biology
Abstract: Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.
ISSN: 1545-9993
DOI: 10.1038/s41594-022-00729-3
Schools: School of Biological Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2022 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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