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https://hdl.handle.net/10356/163031| Title: | The total synthesis of raistrickindole A | Authors: | Pham, Thang Loi Sae-Lao, Patcharaporn Toh, Hannah Hui Min Csókás, Dániel Bates, Roderick Wayland |
Keywords: | Science::Chemistry | Issue Date: | 2022 | Source: | Pham, T. L., Sae-Lao, P., Toh, H. H. M., Csókás, D. & Bates, R. W. (2022). The total synthesis of raistrickindole A. Journal of Organic Chemistry. https://dx.doi.org/10.1021/acs.joc.2c02033 | Project: | NRF-CRP18-2017-01 | Journal: | Journal of Organic Chemistry | Abstract: | The total synthesis of raistrickindole A has been achieved, thereby confirming the proposed structure as an N-hydroxylated DKP. In the first but less selective approach, the DKP was built up by cyclization of a diastereoisomerically mixed N-hydroxylated dipeptide. In the second approach, the same DKP was constructed stereoselectively by the intramolecular Mitsunobu reaction of a hydroxamic acid. The synthesis was completed by a stereoselective oxidative cyclization. | URI: | https://hdl.handle.net/10356/163031 | ISSN: | 0022-3263 | DOI: | 10.1021/acs.joc.2c02033 | Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.2c02033. | Fulltext Permission: | embargo_20231118 | Fulltext Availability: | With Fulltext |
| Appears in Collections: | CCEB Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Raistrickindole JOC revised v2.pdf Until 2023-11-18 | 367.4 kB | Adobe PDF | Under embargo until Nov 18, 2023 |
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