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https://hdl.handle.net/10356/163058
Title: | Tailored quantum dots for enhancing sensing performance of lateral flow immunoassay | Authors: | Fang, Bolong Xiong, Qirong Duan, Hongwei Xiong, Yonghua Lai, Weihua |
Keywords: | Engineering::Chemical engineering | Issue Date: | 2022 | Source: | Fang, B., Xiong, Q., Duan, H., Xiong, Y. & Lai, W. (2022). Tailored quantum dots for enhancing sensing performance of lateral flow immunoassay. TrAC Trends in Analytical Chemistry, 157, 116754-. https://dx.doi.org/10.1016/j.trac.2022.116754 | Journal: | TrAC Trends in Analytical Chemistry | Abstract: | Lateral flow immunoassay (LFIA), a prominent rapid detection technology, has been widespreadly exploited in the areas of food safety, environmental monitoring, and clinical diagnosis. Nevertheless, a notable restriction of the conventional gold nanoparticles (AuNPs)-based LFIA lies in relatively low sensitivity considering insufficient brightness. Generally, fluorescent LFIA (FLFIA) in which quantum dots (QDs) are deemed as one of the most commonly used signal labels shows higher sensitivity than the conventional AuNPs-based one because of their excellent luminescent properties. In this review, we systematically and comprehensively summarize the emerging strategies of tailing QDs to promote sensing performance of LFIA, including (i) quantum yield enhancement, (ii) QD loading, (iii) antibody labelling method improvement, (iv) background interference reduction, (v) fluorescence quenching, and (vi) nanoparticle flow rate regulation. Further, we put forward the developing status and future outlook on the QDs-based LFIA, which will drive the potential of biosensing applications. | URI: | https://hdl.handle.net/10356/163058 | ISSN: | 0165-9936 | DOI: | 10.1016/j.trac.2022.116754 | Schools: | School of Chemical and Biomedical Engineering | Rights: | © 2022 Elsevier B.V. All rights reserved. This paper was published in TrAC Trends in Analytical Chemistry and is made available with permission of Elsevier B.V. | Fulltext Permission: | embargo_20250107 | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Journal Articles |
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Tailored quantum dots for enhancing sensing performance of lateral flow immunoassay.pdf Until 2025-01-07 | 1.85 MB | Adobe PDF | Under embargo until Jan 07, 2025 |
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