Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163062
Title: The structural basis of β2 integrin intra-cellular multi-protein complexes
Authors: Bhattacharjya, Surajit
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Bhattacharjya, S. (2022). The structural basis of β2 integrin intra-cellular multi-protein complexes. Biophysical Reviews, 14(5), 1183-1195. https://dx.doi.org/10.1007/s12551-022-00995-x
Journal: Biophysical Reviews
Abstract: In multicellular organisms, cell adhesion is a pivotal physiological process which is essential for cell-cell communications, cell migration, and interactions with extracellular matrix. Integrins, a family of large hetero-dimeric type I membrane proteins, are known for driving cell adhesion functions. Among 24 different integrins, four β2 integrins, αL β2, αM β2, αX β2 and αD β2, are specific for cell adhesion and migration of leukocytes. Many cytosolic proteins interact with short cytosolic tails (CTs) of β2 and other integrins which are essential in bi-directional signaling processes. Further, phosphorylation of CTs of integrins regulates binding of intra-cellular proteins and signaling systems. In this review, recent advances in structures and interactions of multi-protein complexes of integrin tails, with a focus on β2 integrin, and cytosolic proteins are discussed along with a proposed future direction.
URI: https://hdl.handle.net/10356/163062
ISSN: 1867-2450
DOI: 10.1007/s12551-022-00995-x
Rights: © 2022 International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved. This paper was published in Biophysical Reviews and is made available with permission of International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.
Fulltext Permission: embargo_20231107
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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