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Title: Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection
Authors: Tay, Matthew Zirui
Rouers, Angeline
Fong, Siew-Wai
Goh, Yun Shan
Chan, Yi-Hao
Chang, Zi Wei
Xu, Weili
Tan, Chee Wah
Chia, Wan Ni
Torres-Ruesta, Anthony
Siti Naqiah Amrun
Huang, Yuling
Hor, Pei Xiang
Loh, Chiew Yee
Yeo, Nicholas Kim-Wah
Wang, Bei
Ngoh, Eve Zi Xian
Siti Nazihah Mohd Salleh
Chavatte, Jean-Marc
Lim, Alicia Jieling
Maurer-Stroh, Sebastian
Wang, Lin-Fa
Lin, Raymond Valentine Tzer Pin
Wang, Cheng-I
Tan, Seow-Yen
Young, Barnaby Edward
Leo, Yee Sin
Lye, David C.
Renia, Laurent
Ng, Lisa F. P.
Keywords: Science::Medicine
Issue Date: 2022
Source: Tay, M. Z., Rouers, A., Fong, S., Goh, Y. S., Chan, Y., Chang, Z. W., Xu, W., Tan, C. W., Chia, W. N., Torres-Ruesta, A., Siti Naqiah Amrun, Huang, Y., Hor, P. X., Loh, C. Y., Yeo, N. K., Wang, B., Ngoh, E. Z. X., Siti Nazihah Mohd Salleh, Chavatte, J., ...Ng, L. F. P. (2022). Decreased memory B cell frequencies in COVID-19 delta variant vaccine breakthrough infection. EMBO Molecular Medicine, 14(3), e15227-.
Project: ACCL/19-GAP064-R20H-H 
Journal: EMBO Molecular Medicine 
Abstract: The SARS-CoV-2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as to whether deficiencies in specific vaccine-elicited immune responses result in susceptibility to vaccine breakthrough infection. We investigated 55 vaccine breakthrough infection cases (mostly Delta) in Singapore, comparing them against 86 vaccinated close contacts who did not contract infection. Vaccine breakthrough cases showed lower memory B cell frequencies against SARS-CoV-2 receptor-binding domain (RBD). Compared to plasma antibodies, antibodies secreted by memory B cells retained a higher fraction of neutralizing properties against the Delta variant. Inflammatory cytokines including IL-1β and TNF were lower in vaccine breakthrough infections than primary infection of similar disease severity, underscoring the usefulness of vaccination in preventing inflammation. This report highlights the importance of memory B cells against vaccine breakthrough and suggests that lower memory B cell levels may be a correlate of risk for Delta vaccine breakthrough infection.
ISSN: 1757-4676
DOI: 10.15252/emmm.202115227
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: A*STAR Infectious Diseases Labs
Singapore Immunology Network, A*STAR
National Centre for Infectious Diseases, Singapore
Tan Tock Seng Hospital
Yong Loo Lin School of Medicine, NUS
Rights: © 2022 The Authors. Published under the terms of the CC BY 4.0 license.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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