Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163098
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPayne, Magalien_US
dc.contributor.authorManera, Valeriaen_US
dc.contributor.authorRobert, Philippeen_US
dc.contributor.authorVandersteen, Clairen_US
dc.contributor.authorBeauchet, Olivieren_US
dc.contributor.authorGalery, Kevinen_US
dc.contributor.authorSacco, Guillaumeen_US
dc.contributor.authorFabre, Roxaneen_US
dc.contributor.authorGros, Aurianeen_US
dc.date.accessioned2022-11-21T06:13:37Z-
dc.date.available2022-11-21T06:13:37Z-
dc.date.issued2022-
dc.identifier.citationPayne, M., Manera, V., Robert, P., Vandersteen, C., Beauchet, O., Galery, K., Sacco, G., Fabre, R. & Gros, A. (2022). Olfactory identification disorders due to Alzheimer's disease: a new test from France to Quebec. PloS One, 17(4), e0265764-. https://dx.doi.org/10.1371/journal.pone.0265764en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://hdl.handle.net/10356/163098-
dc.description.abstractOlfactory identification disorder is regarded as an early marker of Alzheimer's disease (AD) and of similar diagnostic significance of biological or cognitive markers. Premature damage of the entorhinal olfactory cortex, the hippocampus and the orbitofrontal cortex characterize AD and suggest a specific impairment of olfactory identification. The use of psychophysical olfactory identification tests in clinical diagnostic practice is therefore strongly recommended, but not required. As these widespread tests are rarely used, an innovative test, adapted to this target group has been developed. It has been used and validated in a routine care protocol at different Memory Centers in France and in Quebec, Canada. A total of 157 participants were recruited: including 63 Alzheimer's patients and 94 healthy controls. The test was composed of 14 odorants diluted into 4 different concentrations. A computer interface generated randomization of 6 odors per participant and the automatic calculation of identification scores, of perceptual thresholds and of composite scores. All participants underwent a Mini Mental Scale Examination within the previous three months or on the same day of the olfactory test. The Alzheimer's patients had a score between 20 and 30 and healthy controls participants had a score above 28 without any loss of points on recalled items. The results show that our olfactory identification test is able to significantly differentiate Alzheimer's patients from healthy controls (p < 0.001), and to distinguish the French population tested from the Quebec population (p < 0.001). This study highlights an olfactory identification disorder as a target for early diagnosis of AD. Its cultural qualities make it a potential candidate for differentiated calibration between France and Quebec.en_US
dc.language.isoenen_US
dc.relation.ispartofPloS oneen_US
dc.rights© 2022 Payne et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectScience::Medicineen_US
dc.titleOlfactory identification disorders due to Alzheimer's disease: a new test from France to Quebecen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1371/journal.pone.0265764-
dc.description.versionPublished versionen_US
dc.identifier.pmid35377902-
dc.identifier.scopus2-s2.0-85127529860-
dc.identifier.issue4en_US
dc.identifier.volume17en_US
dc.identifier.spagee0265764en_US
dc.subject.keywordsAlzheimer Diseaseen_US
dc.subject.keywordsSmelling Disorderen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
Files in This Item:
File Description SizeFormat 
journal.pone.0265764.pdf1.2 MBAdobe PDFView/Open

SCOPUSTM   
Citations 50

3
Updated on Feb 6, 2023

Web of ScienceTM
Citations 50

3
Updated on Feb 5, 2023

Page view(s)

18
Updated on Feb 8, 2023

Download(s)

3
Updated on Feb 8, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.