Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163113
Title: Mechanisms of weight loss after obesity surgery
Authors: Akalestou, Elina
Miras, Alexander D.
Rutter, Guy A.
le Roux, Carel W.
Keywords: Science::Medicine
Issue Date: 2022
Source: Akalestou, E., Miras, A. D., Rutter, G. A. & le Roux, C. W. (2022). Mechanisms of weight loss after obesity surgery. Endocrine Reviews, 43(1), 19-34. https://dx.doi.org/10.1210/endrev/bnab022
Journal: Endocrine Reviews
Abstract: Obesity surgery remains the most effective treatment for obesity and its complications. Weight loss was initially attributed to decreased energy absorption from the gut but has since been linked to reduced appetitive behavior and potentially increased energy expenditure. Implicated mechanisms associating rearrangement of the gastrointestinal tract with these metabolic outcomes include central appetite control, release of gut peptides, change in microbiota, and bile acids. However, the exact combination and timing of signals remain largely unknown. In this review, we survey recent research investigating these mechanisms, and seek to provide insights on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.
URI: https://hdl.handle.net/10356/163113
ISSN: 0163-769X
DOI: 10.1210/endrev/bnab022
Rights: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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