Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163134
Title: A dual-mode NADH biosensor based on gold nanostars decorated CoFe₂ metal–organic frameworks to reveal dynamics of cell metabolism
Authors: Zhao, Xiaoping
Niu, Ruoxin
Fan, Shu
Jing, Xunan
Gao, Rui
Yang, Hongbo
Wang, Heng
Wang, Daquan
Yang, Zhiwei
Xie, Yunchuan
She, Junjun
Chen, Peng
Meng, Lingjie
Keywords: Science::Chemistry
Issue Date: 2022
Source: Zhao, X., Niu, R., Fan, S., Jing, X., Gao, R., Yang, H., Wang, H., Wang, D., Yang, Z., Xie, Y., She, J., Chen, P. & Meng, L. (2022). A dual-mode NADH biosensor based on gold nanostars decorated CoFe₂ metal–organic frameworks to reveal dynamics of cell metabolism. ACS Sensors, 7(9), 2671-2679. https://dx.doi.org/10.1021/acssensors.2c01175
Project: RG110/20
RT02/20
MOE2019-T2-2-004
Journal: ACS Sensors
Abstract: Nicotinamide adenine dinucleotide (NADH) is central to metabolism and implicated in various diseases. Herein, nanohybrids of gold nanostars and metal-organic frameworks are devised and demonstrated as a dual-mode NADH sensor, for which colorimetric detection is enabled by its peroxidase-like nanozyme property and Raman detection is realized by its surface-enhanced Raman scattering property with the detection limit as low as 28 pM. More importantly, this probe enables real-time SERS monitoring in living cells, providing a unique tool to investigate dynamic cellular processes involving NADH. Our experiments reveal that metabolism dynamics is accelerated by glucose and is much higher in cancerous cells. The SERS results can also be verified by the colorimetric detection. This sensor provides a new potential to detect biomarkers and their dynamics in situ.
URI: https://hdl.handle.net/10356/163134
ISSN: 2379-3694
DOI: 10.1021/acssensors.2c01175
Rights: © 2022 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:CCEB Journal Articles

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