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dc.contributor.authorZhao, Xiaopingen_US
dc.contributor.authorNiu, Ruoxinen_US
dc.contributor.authorFan, Shuen_US
dc.contributor.authorJing, Xunanen_US
dc.contributor.authorGao, Ruien_US
dc.contributor.authorYang, Hongboen_US
dc.contributor.authorWang, Hengen_US
dc.contributor.authorWang, Daquanen_US
dc.contributor.authorYang, Zhiweien_US
dc.contributor.authorXie, Yunchuanen_US
dc.contributor.authorShe, Junjunen_US
dc.contributor.authorChen, Pengen_US
dc.contributor.authorMeng, Lingjieen_US
dc.identifier.citationZhao, X., Niu, R., Fan, S., Jing, X., Gao, R., Yang, H., Wang, H., Wang, D., Yang, Z., Xie, Y., She, J., Chen, P. & Meng, L. (2022). A dual-mode NADH biosensor based on gold nanostars decorated CoFe₂ metal–organic frameworks to reveal dynamics of cell metabolism. ACS Sensors, 7(9), 2671-2679.
dc.description.abstractNicotinamide adenine dinucleotide (NADH) is central to metabolism and implicated in various diseases. Herein, nanohybrids of gold nanostars and metal-organic frameworks are devised and demonstrated as a dual-mode NADH sensor, for which colorimetric detection is enabled by its peroxidase-like nanozyme property and Raman detection is realized by its surface-enhanced Raman scattering property with the detection limit as low as 28 pM. More importantly, this probe enables real-time SERS monitoring in living cells, providing a unique tool to investigate dynamic cellular processes involving NADH. Our experiments reveal that metabolism dynamics is accelerated by glucose and is much higher in cancerous cells. The SERS results can also be verified by the colorimetric detection. This sensor provides a new potential to detect biomarkers and their dynamics in situ.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofACS Sensorsen_US
dc.rights© 2022 American Chemical Society. All rights reserved.en_US
dc.titleA dual-mode NADH biosensor based on gold nanostars decorated CoFe₂ metal–organic frameworks to reveal dynamics of cell metabolismen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemistry, Chemical Engineering and Biotechnologyen_US
dc.subject.keywordsSurface-Enhanced Raman Scatteringen_US
dc.subject.keywordsMetal−Organic Frameworksen_US
dc.description.acknowledgementThis work was supported by the National Natural Science Foundation of China (21674085), National Postdoctoral Program for Innovative Talent (BX20190277), the Natural Science Basic Research Plan in Shaanxi Province of China (2020JZ-01), the China Postdoctoral Science Foundation (2020M673387, 2021M702557), the Key Laboratory Construction Program of Xi’an Municipal Bureau of Science and Technology (201805056ZD7CG40), the youth talent support program of Xi’an Jiaotong University (HX6J016) and Singapore Ministry of Education under its Academic Research Fund (AcRF) Tier-1 grants (RG110/20 and RT02/20) and AcRF Tier-2 grant (MOE2019-T2-2-004).en_US
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