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Title: Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans
Authors: Chen, Liwei
Zheng, Tingting
Yang, Yifan
Chaudhary, Prem Prashant
Teh, Jean Pui Yi
Cheon, Bobby Kyungbeom
Moses, Daniela
Schuster, Stephan Christoph
Schlundt, Joergen
Li, Jun
Conway, Patricia Lynne
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Chen, L., Zheng, T., Yang, Y., Chaudhary, P. P., Teh, J. P. Y., Cheon, B. K., Moses, D., Schuster, S. C., Schlundt, J., Li, J. & Conway, P. L. (2022). Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans. Gut Microbes, 14(1), 2070392-.
Project: NIM/ 06/2016 
Journal: Gut Microbes 
Abstract: The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in Singapore adults. We conducted shotgun metagenomic sequencing of fecal and saliva samples, as well as fecal metabolomics to characterize the gut and oral microbial communities of 62 healthy adult male Singaporeans, including 32 young subjects (age, 23.1 ± 1.4 years) and 30 elderly subjects (age, 69.0 ± 3.5 years). We identified 8 gut and 13 oral species that were differentially abundant in elderly compared to young subjects. By combining the gut and oral microbiomes, 25 age-associated oral-gut species connections were identified. Moreover, oral bacteria Acidaminococcus intestine and Flavonifractor plautii were less prevalent/abundant in elderly gut samples than in young gut samples, whereas Collinsella aerofaciens and Roseburia hominis showed the opposite trends. These results indicate the varied gut-oral communications with aging. Subsequently, we expanded the association studies on microbiome, metabolome and host phenotypic parameters. In particular, Eubacterium eligens increased in elderly compared to young subjects, and was positively correlated with triglycerides, which implies that the potential role of E. eligens in lipid metabolism is altered during the aging process. Our results demonstrated aging-associated changes in the gut and oral microbiomes, as well as the connections between metabolites and host-microbe interactions, thereby deepening the understanding of alterations in the human microbiome during the aging process in a Singapore population.
ISSN: 1949-0976
DOI: 10.1080/19490976.2022.2070392
Schools: School of Chemical and Biomedical Engineering 
National Institute of Education 
School of Social Sciences 
Research Centres: Nanyang Technological University Food Technology Centre (NAFTEC)
Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) 
Rights: © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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