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https://hdl.handle.net/10356/163158
Title: | Strategies to mitigate establishment under the Wolbachia incompatible insect technique | Authors: | Soh, Stacy Ho, Soon Hoe Ong, Janet Seah, Annabel Dickens, Borame Sue Tan, Ken Wei Koo, Joel Ruihan Cook, Alex R. Sim, Shuzhen Tan, Cheong Huat Ng, Lee Ching Lim, Jue Tao |
Keywords: | Science::Biological sciences | Issue Date: | 2022 | Source: | Soh, S., Ho, S. H., Ong, J., Seah, A., Dickens, B. S., Tan, K. W., Koo, J. R., Cook, A. R., Sim, S., Tan, C. H., Ng, L. C. & Lim, J. T. (2022). Strategies to mitigate establishment under the Wolbachia incompatible insect technique. Viruses, 14(6), 1132-. https://dx.doi.org/10.3390/v14061132 | Journal: | Viruses | Abstract: | The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium Wolbachia. Regular releases of male Wolbachia-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of vector-borne diseases such as dengue. However, due to imperfect sex-sorting under IIT, fertile Wolbachia-infected female mosquitoes may potentially be unintentionally released into the environment, which may result in replacement and failure to suppress the mosquito populations. As such, mitigating Wolbachia establishment requires a combination of IIT with other strategies. We introduced a simple compartmental model to simulate ex-ante mosquito population dynamics subjected to a Wolbachia-IIT programme. In silico, we explored the risk of replacement, and strategies that could mitigate the establishment of the released Wolbachia strain in the mosquito population. Our results suggest that mitigation may be achieved through the application of a sterile insect technique. Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of Wolbachia using the IIT population control strategy. | URI: | https://hdl.handle.net/10356/163158 | ISSN: | 1999-4915 | DOI: | 10.3390/v14061132 | Schools: | School of Biological Sciences | Organisations: | National Environment Agency | Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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viruses-14-01132-v2.pdf | 2.99 MB | Adobe PDF | View/Open |
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