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Title: Strategies to mitigate establishment under the Wolbachia incompatible insect technique
Authors: Soh, Stacy
Ho, Soon Hoe
Ong, Janet
Seah, Annabel
Dickens, Borame Sue
Tan, Ken Wei
Koo, Joel Ruihan
Cook, Alex R.
Sim, Shuzhen
Tan, Cheong Huat
Ng, Lee Ching
Lim, Jue Tao
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Soh, S., Ho, S. H., Ong, J., Seah, A., Dickens, B. S., Tan, K. W., Koo, J. R., Cook, A. R., Sim, S., Tan, C. H., Ng, L. C. & Lim, J. T. (2022). Strategies to mitigate establishment under the Wolbachia incompatible insect technique. Viruses, 14(6), 1132-.
Journal: Viruses
Abstract: The Incompatible Insect Technique (IIT) strategy involves the release of male mosquitoes infected with the bacterium Wolbachia. Regular releases of male Wolbachia-infected mosquitoes can lead to the suppression of mosquito populations, thereby reducing the risk of transmission of vector-borne diseases such as dengue. However, due to imperfect sex-sorting under IIT, fertile Wolbachia-infected female mosquitoes may potentially be unintentionally released into the environment, which may result in replacement and failure to suppress the mosquito populations. As such, mitigating Wolbachia establishment requires a combination of IIT with other strategies. We introduced a simple compartmental model to simulate ex-ante mosquito population dynamics subjected to a Wolbachia-IIT programme. In silico, we explored the risk of replacement, and strategies that could mitigate the establishment of the released Wolbachia strain in the mosquito population. Our results suggest that mitigation may be achieved through the application of a sterile insect technique. Our simulations indicate that these interventions do not override the intended wild type suppression of the IIT approach. These findings will inform policy makers of possible ways to mitigate the potential establishment of Wolbachia using the IIT population control strategy.
ISSN: 1999-4915
DOI: 10.3390/v14061132
Schools: School of Biological Sciences 
Organisations: National Environment Agency
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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