Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163159
Title: Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications
Authors: Mieles, Joel Yupanqui
Vyas, Cian
Aslan, Enes
Humphreys, Gavin
Diver, Carl
Bartolo, Paulo
Keywords: Engineering::Mechanical engineering
Issue Date: 2022
Source: Mieles, J. Y., Vyas, C., Aslan, E., Humphreys, G., Diver, C. & Bartolo, P. (2022). Honey: an advanced antimicrobial and wound healing biomaterial for tissue engineering applications. Pharmaceutics, 14(8), 14081663-. https://dx.doi.org/10.3390/pharmaceutics14081663
Journal: Pharmaceutics 
Abstract: Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey's antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey's active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey's antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds.
URI: https://hdl.handle.net/10356/163159
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics14081663
Schools: School of Mechanical and Aerospace Engineering 
Research Centres: Singapore Centre for 3D Printing 
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
SC3DP Journal Articles

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