Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163232
Title: Meta-analyses identify DNA methylation associated with kidney function and damage
Authors: Schlosser, Pascal
Tin, Adrienne
Matias-Garcia, Pamela R.
Thio, Chris H. L.
Joehanes, Roby
Liu, Hongbo
Weihs, Antoine
Yu, Zhi
Hoppmann, Anselm
Grundner-Culemann, Franziska
Min, Josine L.
Adeyemo, Adebowale A.
Agyemang, Charles
Ärnlöv, Johan
Aziz, Nasir A.
Baccarelli, Andrea
Bochud, Murielle
Brenner, Hermann
Breteler, Monique M. B.
Carmeli, Cristian
Chaker, Layal
Chambers, John C.
Cole, Shelley A.
Coresh, Josef
Corre, Tanguy
Correa, Adolfo
Cox, Simon R.
de Klein, Niek
Delgado, Graciela E.
Domingo-Relloso, Arce
Eckardt, Kai-Uwe
Ekici, Arif B.
Endlich, Karlhans
Evans, Kathryn L.
Floyd, James S.
Fornage, Myriam
Franke, Lude
Fraszczyk, Eliza
Gao, Xu
Gào, Xīn
Ghanbari, Mohsen
Ghasemi, Sahar
Gieger, Christian
Greenland, Philip
Grove, Megan L.
Harris, Sarah E.
Hemani, Gibran
Henneman, Peter
Herder, Christian
Horvath, Steve
Hou, Lifang
Hurme, Mikko A.
Hwang, Shih-Jen
Jarvelin, Marjo-Riitta
Kardia, Sharon L. R.
Kasela, Silva
Kleber, Marcus E.
Koenig, Wolfgang
Kooner, Jaspal S.
Kramer, Holly
Kronenberg, Florian
Kühnel, Brigitte
Lehtimäki, Terho
Lind, Lars
Liu, Dan
Liu, Yongmei
Lloyd-Jones, Donald M.
Lohman, Kurt
Lorkowski, Stefan
Lu, Ake T.
Marioni, Riccardo E.
März, Winfried
McCartney, Daniel L.
Meeks, Karlijn A. C.
Milani, Lili
Mishra, Pashupati P.
Nauck, Matthias
Navas-Acien, Ana
Nowak, Christoph
Peters, Annette
Prokisch, Holger
Psaty, Bruce M.
Raitakari, Olli T.
Ratliff, Scott M.
Reiner, Alex P.
Rosas, Sylvia E.
Schöttker, Ben
Schwartz, Joel
Sedaghat, Sanaz
Smith, Jennifer A.
Sotoodehnia, Nona
Stocker, Hannah R.
Stringhini, Silvia
Sundström, Johan
Swenson, Brenton R.
Tellez-Plaza, Maria
van Meurs, Joyce B. J.
van Vliet-Ostaptchouk, Jana V.
Venema, Andrea
Verweij, Niek
Walker, Rosie M.
Wielscher, Matthias
Winkelmann, Juliane
Wolffenbuttel, Bruce H. R.
Zhao, Wei
Zheng, Yinan
Milani, Lili
Esko, Tõnu
Metspalu, Andres
Mägi, Reedik
Nelis, Mari
Min, Josine L.
Hemani, Gibran
Loh, Marie
Snieder, Harold
Levy, Daniel
Waldenberger, Melanie
Susztak, Katalin
Köttgen, Anna
Teumer, Alexander
Keywords: Science::Medicine
Issue Date: 2021
Source: Schlosser, P., Tin, A., Matias-Garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H., Weihs, A., Yu, Z., Hoppmann, A., Grundner-Culemann, F., Min, J. L., Adeyemo, A. A., Agyemang, C., Ärnlöv, J., Aziz, N. A., Baccarelli, A., Bochud, M., Brenner, H., Breteler, M. M. B., ...Teumer, A. (2021). Meta-analyses identify DNA methylation associated with kidney function and damage. Nature Communications, 12(1), 7174-. https://dx.doi.org/10.1038/s41467-021-27234-3
Project: NMRC/STaR/0028/2017 
Journal: Nature Communications 
Abstract: Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
URI: https://hdl.handle.net/10356/163232
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27234-3
Rights: © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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