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Title: A chemically mediated artificial neuron
Authors: Wang, Ting
Wang, Ming
Wang, Jianwu
Yang, Le
Ren, Xueyang
Song, Gang
Chen, Shisheng
Yuan, Yuehui
Liu, Ruiqing
Pan, Liang
Li, Zheng
Leow, Wan Ru
Luo, Yifei
Ji, Shaobo
Cui, Zequn
He, Ke
Zhang, Feilong
Lv, Fengting
Tian, Yuanyuan
Cai, Kaiyu
Yang, Bowen.
Niu, Jingyi
Zou, Haochen
Liu, Songrui
Xu, Guoliang
Fan, Xing
Hu, Benhui
Loh, Xian Jun
Wang, Lianhui
Chen, Xiaodong
Keywords: Engineering::Materials
Issue Date: 2022
Source: Wang, T., Wang, M., Wang, J., Yang, L., Ren, X., Song, G., Chen, S., Yuan, Y., Liu, R., Pan, L., Li, Z., Leow, W. R., Luo, Y., Ji, S., Cui, Z., He, K., Zhang, F., Lv, F., Tian, Y., ...Chen, X. (2022). A chemically mediated artificial neuron. Nature Electronics, 5(9), 586-595.
Project: A18A1b0045 
Journal: Nature Electronics 
Abstract: Brain–machine interfaces typically rely on electrophysiological signals to interpret and transmit neurological information. In biological systems, however, neurotransmitters are chemical-based interneuron messengers. This mismatch can potentially lead to incorrect interpretation of the transmitted neuron information. Here we report a chemically mediated artificial neuron that can receive and release the neurotransmitter dopamine. The artificial neuron detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release through a heat-responsive hydrogel. The system responds to dopamine exocytosis from rat pheochromocytoma cells and also releases dopamine to activate pheochromocytoma cells, forming a chemical communication loop similar to interneurons. To illustrate the potential of this approach, we show that the artificial neuron can trigger the controllable movement of a mouse leg and robotic hand.
ISSN: 2520-1131
DOI: 10.1038/s41928-022-00803-0
Schools: School of Materials Science and Engineering 
Research Centres: Innovative Centre for Flexible Devices 
Rights: © 2022 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved. This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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