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Title: Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy
Authors: You, Changwen
Li, Xingguang
Wang, Dongqiong
Chen, Hongzhong
Liang, Lei
Chen, Yu
Zhao, Yanli
Xiang, Huijing
Keywords: Science::Chemistry
Issue Date: 2022
Source: You, C., Li, X., Wang, D., Chen, H., Liang, L., Chen, Y., Zhao, Y. & Xiang, H. (2022). Self-assembled Aza-boron-dipyrromethene for ferroptosis-boosted sonodynamic therapy. Angewandte Chemie International Edition, 61(41), e202210174-.
Project: NRF-NRFI2018-03
Journal: Angewandte Chemie International Edition
Abstract: The presence of apoptosis inhibition proteins renders the cancer cells resistant to apoptosis, severely compromising the antitumor efficacy of sonodynamic therapy (SDT). Here, an intelligent anticancer nanoplatform based on an Aza-boron-dipyrromethene dye (denoted as Aza-BDY) is elaborately established for ferroptosis augmented SDT through cysteine (Cys) starvation. After endocytosis by tumor cells, Aza-BDY serves as both a ferroptosis inducing agent and a sonosensitizer for tumor treatment. The specific Cys response facilitates the disruption of redox homeostasis and initiation of cellular ferroptosis. Meanwhile, the released sonosensitizer causes efficient SDT and augments ferroptosis under ultrasound irradiation. Detailed in vitro and in vivo investigations demonstrate that the synergistic effect of Cys depletion and singlet oxygen (1 O2 ) generation significantly induces cancer-cell death and suppresses tumor proliferation with a high inhibition rate of 97.5 %.
ISSN: 1433-7851
DOI: 10.1002/anie.202210174
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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