Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163324
Title: Light-triggered hypoxia-responsive nanoscale metal-organic frameworks for highly efficient antitumor treatment
Authors: Yang, Guangbao
Bindra, Anivind Kaur
Phua, Fiona Soo Zeng
Liu, Jiawei
Wu, Hongwei
Wang, Dongdong
Qian, Cheng
Liu, Guofeng
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Yang, G., Bindra, A. K., Phua, F. S. Z., Liu, J., Wu, H., Wang, D., Qian, C., Liu, G. & Zhao, Y. (2022). Light-triggered hypoxia-responsive nanoscale metal-organic frameworks for highly efficient antitumor treatment. Advanced Optical Materials. https://dx.doi.org/10.1002/adom.202201043
Project: A20E5c0081
NRF-NRFI2018-03
Journal: Advanced Optical Materials
Abstract: Photodynamic therapy (PDT), as a noninvasive therapeutic tool, can result in a high level of hypoxia in tumors. Herein, hypoxia-responsive nanoscale metal-organic frameworks (UiO-AZB) are prepared, which contain an azo group in its organic linker. After modifying the surface of UiO-AZB with chlorin e6 (Ce6)-conjugated human serum albumin (HSA), tirapazamine (TPZ) is employed as a hypoxia-activated prodrug to be encapsulated into UiO-AZB. The obtained nanosystem (UiO-AZB/HC-TPZ) can efficiently produce singlet oxygen under 660 nm light irradiation and cause severe hypoxia in tumors. This process in turn triggers the degradation of the frameworks and controllable release of activated TPZ for chemotherapy, finally leading to improved antitumor treatment through combinational PDT and hypoxia-activated chemotherapy. This research demonstrates a distinctive treatment strategy, that is, using a simple stimulus (light irradiation) to trigger a series of activities (PDT, disintegration of UiO-AZB structure, activation of TPZ, and controllable release) for realizing an effective treatment of tumors.
URI: https://hdl.handle.net/10356/163324
ISSN: 2195-1071
DOI: 10.1002/adom.202201043
Rights: © 2022 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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