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Title: Light-triggered hypoxia-responsive nanoscale metal-organic frameworks for highly efficient antitumor treatment
Authors: Yang, Guangbao
Bindra, Anivind Kaur
Phua, Fiona Soo Zeng
Liu, Jiawei
Wu, Hongwei
Wang, Dongdong
Qian, Cheng
Liu, Guofeng
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Yang, G., Bindra, A. K., Phua, F. S. Z., Liu, J., Wu, H., Wang, D., Qian, C., Liu, G. & Zhao, Y. (2022). Light-triggered hypoxia-responsive nanoscale metal-organic frameworks for highly efficient antitumor treatment. Advanced Optical Materials, 11(11), 2201043-.
Project: A20E5c0081 
Journal: Advanced Optical Materials 
Abstract: Photodynamic therapy (PDT), as a noninvasive therapeutic tool, can result in a high level of hypoxia in tumors. Herein, hypoxia-responsive nanoscale metal-organic frameworks (UiO-AZB) are prepared, which contain an azo group in its organic linker. After modifying the surface of UiO-AZB with chlorin e6 (Ce6)-conjugated human serum albumin (HSA), tirapazamine (TPZ) is employed as a hypoxia-activated prodrug to be encapsulated into UiO-AZB. The obtained nanosystem (UiO-AZB/HC-TPZ) can efficiently produce singlet oxygen under 660 nm light irradiation and cause severe hypoxia in tumors. This process in turn triggers the degradation of the frameworks and controllable release of activated TPZ for chemotherapy, finally leading to improved antitumor treatment through combinational PDT and hypoxia-activated chemotherapy. This research demonstrates a distinctive treatment strategy, that is, using a simple stimulus (light irradiation) to trigger a series of activities (PDT, disintegration of UiO-AZB structure, activation of TPZ, and controllable release) for realizing an effective treatment of tumors.
ISSN: 2195-1071
DOI: 10.1002/adom.202201043
Schools: School of Physical and Mathematical Sciences 
School of Chemistry, Chemical Engineering and Biotechnology 
Rights: © 2022 Wiley-VCH GmbH. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at
Fulltext Permission: embargo_20240612
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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