Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163325
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dc.contributor.authorZhang, Xiaodongen_US
dc.contributor.authorChen, Xiaokaien_US
dc.contributor.authorZhao, Yanlien_US
dc.date.accessioned2022-12-02T05:19:25Z-
dc.date.available2022-12-02T05:19:25Z-
dc.date.issued2022-
dc.identifier.citationZhang, X., Chen, X. & Zhao, Y. (2022). Nanosystems for immune regulation against bacterial infections: a review. ACS Applied Nano Materials, 5(10), 13959-13971. https://dx.doi.org/10.1021/acsanm.2c01380en_US
dc.identifier.issn2574-0970en_US
dc.identifier.urihttps://hdl.handle.net/10356/163325-
dc.description.abstractThe immune system constitutes the fortifications that safeguard the body against bacterial infections. Artificial nanosystems possess many attractive properties including the ability to modulate the immune responses against bacterial infections. On the one hand, antigen-loaded nanosystems have emerged as a promising alternative to convensional vaccines, protecting the host from infection. On the other hand, immunity can be regulated by nanosystems to treat infections caused by bacteria and related diseases. Herein, we initially introduce the recent advances of artificial nanosystems in the development of different vaccines including subunit and toxoid vaccines. Then, we focus on discussing the employment of nanosystems for the activation of immunity, including innate and adaptive immunity, to treat bacteria-induced infectious diseases. In addition, nanosystems with immunosuppressive capabilities are also highlighted, which can restrain the overactivation of immune responses, thereby relieving inflammation in the face of infections. Finally, we discuss current challenges and provide perspectives for future development in this rapidly growing field. Thus, this review is expected to inspire more advanced research of using nanosystems to achieve immune regulation toward practical applications.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationA20E5c0081en_US
dc.relationNRF-NRFI2018-03en_US
dc.relation.ispartofACS Applied Nano Materialsen_US
dc.rights© 2022 American Chemical Society. All rights reserved.en_US
dc.subjectScience::Chemistryen_US
dc.titleNanosystems for immune regulation against bacterial infections: a reviewen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/acsanm.2c01380-
dc.identifier.scopus2-s2.0-85133335586-
dc.identifier.issue10en_US
dc.identifier.volume5en_US
dc.identifier.spage13959en_US
dc.identifier.epage13971en_US
dc.subject.keywordsAdaptive Immunityen_US
dc.subject.keywordsAntibacterial Immunityen_US
dc.description.acknowledgementThis research is supported by the Singapore Agency for Science, Technology and Research (A*STAR) AME IRG (Grant A20E5c0081) and the Singapore National Research Foundation Investigatorship (Grant NRF-NRFI2018-03).en_US
item.grantfulltextnone-
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