Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163368
Title: Relationship of quantitative retinal capillary network and myocardial remodeling in systemic hypertension
Authors: Chua, Jacqueline
Le, Thu-Thao
Sim, Yin Ci
Chye, Hui Yi
Tan, Bingyao
Yao, Xinwen
Wong, Damon
Ang, Briana W. Y.
Toh, Desiree-Faye
Lim, Huishan
Bryant, Jennifer A.
Wong, Tien Yin
Chin, Calvin Woon Loong
Schmetterer, Leopold
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Chua, J., Le, T., Sim, Y. C., Chye, H. Y., Tan, B., Yao, X., Wong, D., Ang, B. W. Y., Toh, D., Lim, H., Bryant, J. A., Wong, T. Y., Chin, C. W. L. & Schmetterer, L. (2022). Relationship of quantitative retinal capillary network and myocardial remodeling in systemic hypertension. Journal of the American Heart Association, 11(6), e024226-. https://dx.doi.org/10.1161/JAHA.121.024226
Project: Duke‐NUS‐KP(Coll)/2018/0009A
CG/C010A/2017_SERI
NMRC/OFLCG/001c/2017
OFIRG/0048/2017
OFLCG/004c/2018
TA/MOH‐000249‐00/2018
MOH‐OFIRG20nov‐0014
NRF2019‐THE002‐0006
NRF‐CRP24‐2020‐0001
A20H4b0141 
LF1019‐1
Journal: Journal of the American Heart Association
Abstract: Background: This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods and Results: We conducted a cross-sectional study of 118 adults with hypertension (197 eyes). Patients underwent cardiovascular magnetic resonance imaging and OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations between OCTA parameters (superficial and deep retinal capillary density) and adverse cardiac remodeling (left ventricular mass, remodeling index, interstitial fibrosis, global longitudinal strain, and presence of left ventricular hypertrophy) were studied using multivariable linear regression analysis with generalized estimating equations. Of the 118 patients with hypertension enrolled (65% men; median [interquartile range] age, 59 [13] years), 29% had left ventricular hypertrophy. After adjusting for age, sex, systolic blood pressure, diabetes, and signal strength of OCTA scans, patients with lower superficial capillary density had significantly higher left ventricular mass (β=-0.150; 95% CI, -0.290 to -0.010), higher interstitial volume (β=-0.270; 95% CI, -0.535 to -0.0015), and worse global longitudinal strain (β=-0.109; 95% CI, -0.187 to -0.032). Lower superficial capillary density was found in patients with hypertension with replacement fibrosis versus no replacement fibrosis (16.53±0.64 mm-1 versus 16.96±0.64 mm-1; P=0.003). Conclusions: We showed significant correlations between retinal capillary density and adverse cardiac remodeling markers in patients with hypertension, supporting the notion that the OCTA could provide a non-invasive index of microcirculation alteration for vascular risk stratification in people with hypertension.
URI: https://hdl.handle.net/10356/163368
ISSN: 2047-9980
DOI: 10.1161/JAHA.121.024226
Rights: © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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