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Title: Leaf morphogenesis: the multifaceted roles of mechanics
Authors: Guo, Kexin
Huang, Changjin
Miao, Yansong
Cosgrove, Daniel J.
Hsia, K. Jimmy
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Guo, K., Huang, C., Miao, Y., Cosgrove, D. J. & Hsia, K. J. (2022). Leaf morphogenesis: the multifaceted roles of mechanics. Molecular Plant, 15(7), 1098-1119.
Project: M4082428 
Journal: Molecular Plant 
Abstract: Plants produce a rich diversity of biological forms, and the diversity of leaves is especially notable. Mechanisms of leaf morphogenesis have been studied in the past two decades, with a growing focus on the interactive roles of mechanics in recent years. Growth of plant organs involves feedback by mechanical stress: growth induces stress, and stress affects growth and morphogenesis. Although much attention has been given to potential stress-sensing mechanisms and cellular responses, the mechanical principles guiding morphogenesis have not been well understood. Here we synthesize the overarching roles of mechanics and mechanical stress in multilevel and multiple stages of leaf morphogenesis, encompassing leaf primordium initiation, phyllotaxis and venation patterning, and the establishment of complex mature leaf shapes. Moreover, the roles of mechanics at multiscale levels, from subcellular cytoskeletal molecules to single cells to tissues at the organ scale, are articulated. By highlighting the role of mechanical buckling in the formation of three-dimensional leaf shapes, this review integrates the perspectives of mechanics and biology to provide broader insights into the mechanobiology of leaf morphogenesis.
ISSN: 1674-2052
DOI: 10.1016/j.molp.2022.05.015
Schools: School of Mechanical and Aerospace Engineering 
School of Biological Sciences 
School of Chemical and Biomedical Engineering 
Rights: © 2022 The Author. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
SBS Journal Articles
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