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dc.contributor.authorZeng, Yongpengen_US
dc.contributor.authorZhuang, Yinyinen_US
dc.contributor.authorVinod, Benjaminen_US
dc.contributor.authorGuo, Xiangfuen_US
dc.contributor.authorMitra, Anindaen_US
dc.contributor.authorChen, Pengen_US
dc.contributor.authorSaggio, Isabellaen_US
dc.contributor.authorShivashankar, G. V.en_US
dc.contributor.authorGao, Weiboen_US
dc.contributor.authorZhao, Wentingen_US
dc.identifier.citationZeng, Y., Zhuang, Y., Vinod, B., Guo, X., Mitra, A., Chen, P., Saggio, I., Shivashankar, G. V., Gao, W. & Zhao, W. (2022). Guiding irregular nuclear morphology on nanopillar arrays for malignancy differentiation in tumor cells. Nano Letters, 22(18), 7724-7733.
dc.description.abstractFor more than a century, abnormal nuclei in tumor cells, presenting subnuclear invaginations and folds on the nuclear envelope, have been known to be associated with high malignancy and poor prognosis. However, current nuclear morphology analysis focuses on the features of the entire nucleus, overlooking the malignancy-related subnuclear features in nanometer scale. The main technical challenge is to probe such tiny and randomly distributed features inside cells. We here employ nanopillar arrays to guide subnuclear features into ordered patterns, enabling their quantification as a strong indicator of cell malignancy. Both breast and liver cancer cells were validated as well as the quantification of nuclear abnormality heterogeneity. The alterations of subnuclear patterns were also explored as effective readouts for drug treatment. We envision that this nanopillar-enabled quantification of subnuclear abnormal features in tumor cells opens a new angle in characterizing malignant cells and studying the unique nuclear biology in cancer.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relationNRF2019-NRF-ISF003- 3292en_US
dc.relation.ispartofNano Lettersen_US
dc.rights© 2022 American Chemical Society. All rights reserved.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleGuiding irregular nuclear morphology on nanopillar arrays for malignancy differentiation in tumor cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemistry, Chemical Engineering and Biotechnologyen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.researchInstitute for Digital Molecular Analytics and Science, NTUen_US
dc.contributor.researchThe Photonics Instituteen_US
dc.contributor.researchCentre for Disruptive Photonic Technologies (CDPT)en_US
dc.subject.keywordsSubnuclear Irregularityen_US
dc.description.acknowledgementThis work is supported by the Singapore Ministry of Education (MOE) (W.Z., RG145/18 and RG112/20), the Singapore National Research Foundation (W.Z., NRF2019-NRF-ISF003- 3292), the Institute for Digital Molecular Analytics and Science (IDMxS) supported by MOE funding under the Research Centres of Excellence scheme (W.Z.), the NTU Start-up Grant (W.Z.), the NTU-NNI Neurotechnology Fellowship (W.Z.), and AIRC IG-24614 and Sapienza AR1181642EE61111 (I.S.).en_US
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