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Title: Biointerface design for vertical nanoprobes
Authors: Elnathan, Roey
Barbato, Maria Grazia
Guo, Xiangfu
Mariano, Anna
Wang, Zixun
Santoro, Francesca
Shi, Peng
Voelcker, Nicolas H.
Xie, Xi
Young, Jennifer L.
Zhao, Yunlong
Zhao, Wenting
Chiappini, Ciro
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Elnathan, R., Barbato, M. G., Guo, X., Mariano, A., Wang, Z., Santoro, F., Shi, P., Voelcker, N. H., Xie, X., Young, J. L., Zhao, Y., Zhao, W. & Chiappini, C. (2022). Biointerface design for vertical nanoprobes. Nature Reviews Materials, 7(12), 953-973.
Project: RG112/20
Journal: Nature Reviews Materials
Abstract: Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical innovations in advanced therapies and diagnostics. The biointerface established by vertical nanoprobes — arrays of vertical high-aspect-ratio nanostructures — has emerged as a simple, controllable and powerful tool for interrogating and manipulating cells. Vertical nanoprobes have substantially improved our ability to control and characterize the intracellular environment, guide biophysical stimuli with nanoscale precision to defined cell compartments, stimulate and record the electrical activity of cells, and transport hard-to-deliver drugs. These capabilities are enabling substantial advances in bioelectronics, spatiotemporally resolved molecular diagnostics, and cell and gene therapy — all underpinned by the design versatility of the nanoprobe biointerface. This Review discusses how the design of a vertical nanoprobe biointerface determines its ability to interrogate and control a cell.
ISSN: 2058-8437
DOI: 10.1038/s41578-022-00464-7
Rights: © Springer Nature Limited 2022. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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