Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/16353
Title: Association study of 3 single-nucleotide polymorphisms of the serum amyloid A1 gene with coronary artery disease in a Singaporean Chinese population.
Authors: Huang, Abigail Yongping.
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 2009
Abstract: Coronary artery disease (CAD) is a complex inflammatory disease that is a leading cause of death in developed countries. The serum amyloid A (SAA) protein family, which has been found to play multiple roles in lipid metabolism and immune regulation, is thought to contribute to CAD development. Previous work in this laboratory has shown that an exonic non-synonymous single nucleotide polymorphism (SNP) in the human SAA1 gene increases CAD risk in a Singaporean Chinese population. Promoter and intronic SNPs could also affect the development of CAD by modulating basal SAA levels. Hence, in this study, a case-control analysis of the association between three non-exonic SNPs of human SAA1 (-2G>A, -250G>A and IVS3+28A>G) and the occurrence of CAD was performed for a Singaporean Chinese population. For each SNP, approximately 350 each of cases and controls were genotyped using allele-specific PCR. The 95% confidence intervals for the allelic odds ratios were 0.68-1.95 (-2G>A), 0.35-1.73 (-250G>A) and 0.71-1.15 (IVS3+28A>G). None of the SNPs were found to contribute significantly to CAD risk in the population.
URI: http://hdl.handle.net/10356/16353
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
SBS08-231.pdf
  Restricted Access
309 kBAdobe PDFView/Open

Page view(s) 50

303
Updated on Nov 28, 2020

Download(s)

3
Updated on Nov 28, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.