Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163570
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dc.contributor.authorJin, Zhichengen_US
dc.contributor.authorLi, Yien_US
dc.contributor.authorLi, Keen_US
dc.contributor.authorZhou, Jiajingen_US
dc.contributor.authorYeung, Justinen_US
dc.contributor.authorLing, Chuxuanen_US
dc.contributor.authorYim, Wonjunen_US
dc.contributor.authorHe, Tengyuen_US
dc.contributor.authorCheng, Yongen_US
dc.contributor.authorXu, Mingen_US
dc.contributor.authorCreyer, Matthew N.en_US
dc.contributor.authorChang, Yu-Cien_US
dc.contributor.authorFajtová, Pavlaen_US
dc.contributor.authorRetout, Mauriceen_US
dc.contributor.authorQi, Baiyanen_US
dc.contributor.authorLi, Shuzhouen_US
dc.contributor.authorO'Donoghue, Anthony J.en_US
dc.contributor.authorJokerst, Jesse V.en_US
dc.date.accessioned2022-12-09T07:38:27Z-
dc.date.available2022-12-09T07:38:27Z-
dc.date.issued2022-
dc.identifier.citationJin, Z., Li, Y., Li, K., Zhou, J., Yeung, J., Ling, C., Yim, W., He, T., Cheng, Y., Xu, M., Creyer, M. N., Chang, Y., Fajtová, P., Retout, M., Qi, B., Li, S., O'Donoghue, A. J. & Jokerst, J. V. (2022). Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing. Angewandte Chemie International Edition. https://dx.doi.org/10.1002/ange.202214394en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/163570-
dc.description.abstractAromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these interactions can be replicated in an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co-assembly experiments with plasmonic gold and surfactant-like peptides (SLPs) spanning a wide range of aromatic residues, polar stretches, and interfacial affinities. The SLPs programmed in DDD−(ZZ)x−FFPC self-assemble into higher-order structures in response to a protease and subsequently modulate the colloidal dispersity of gold leading to a colorimetric readout. Resultsshow the strong aggregation propensity of the FFPC tail without polar DDD head. The SLPs were specific to the target protease, i.e., Mpro, a biomarker for SARS-CoV-2. This system is a simple and visual tool that senses Mproin phosphate buffer, exhaled breath condensate, and saliva with detection limits of 15.7, 20.8, and 26.1 nM, respectively. These results may have value in designing other protease testing methods.en_US
dc.language.isoenen_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rights© 2022 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. This is the peer reviewed version of the following article: Jin, Z., Li, Y., Li, K., Zhou, J., Yeung, J., Ling, C., Yim, W., He, T., Cheng, Y., Xu, M., Creyer, M. N., Chang, Y., Fajtová, P., Retout, M., Qi, B., Li, S., O'Donoghue, A. J. & Jokerst, J. V. (2022). Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing. Angewandte Chemie International Edition, which has been published in final form at https://doi.org/10.1002/ange.202214394. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectEngineering::Materialsen_US
dc.titlePeptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensingen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.organizationInstitute of Materials Research and Engineering, A*STARen_US
dc.identifier.doi10.1002/ange.202214394-
dc.description.versionSubmitted/Accepted versionen_US
dc.subject.keywordsMain Proteaseen_US
dc.subject.keywordsColorimetric Testen_US
dc.description.acknowledgementThe authors thank internal funding from the UC Office of the President (R00RG2515) and the National Institutes of Health (R01 DE031114; R21 AG065776-S1; R21 AI157957) for financial support. This work was also supported by National Science Foundation (DMR-2011924) via equipment in the UC San Diego Materials Research Science and Engineering Center (UCSD MRSEC). M.N.C. was supported by NIT under T32 CA15391.M.R. acknowledges the Wallonie-Bruxelles International (WBI) of the Fédération Wallonie-Bruxelles for financial support. The electron microscopy work was performed in part at the San Diego Nanotechnology Infrastructure (SDNI) of University of California San Diego, a member of the National Nanotechnology Coordinated Infrastructure (NNCI), which is supported by the National Science Foundation (Grant ECCS-1542148). The MANTA analysis work was supported by the National Institutes of Health (S10 OD023555).en_US
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