Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163570
Title: Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing
Authors: Jin, Zhicheng
Li, Yi
Li, Ke
Zhou, Jiajing
Yeung, Justin
Ling, Chuxuan
Yim, Wonjun
He, Tengyu
Cheng, Yong
Xu, Ming
Creyer, Matthew N.
Chang, Yu-Ci
Fajtová, Pavla
Retout, Maurice
Qi, Baiyan
Li, Shuzhou
O'Donoghue, Anthony J.
Jokerst, Jesse V.
Keywords: Engineering::Materials
Issue Date: 2022
Source: Jin, Z., Li, Y., Li, K., Zhou, J., Yeung, J., Ling, C., Yim, W., He, T., Cheng, Y., Xu, M., Creyer, M. N., Chang, Y., Fajtová, P., Retout, M., Qi, B., Li, S., O'Donoghue, A. J. & Jokerst, J. V. (2022). Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing. Angewandte Chemie International Edition. https://dx.doi.org/10.1002/ange.202214394
Journal: Angewandte Chemie International Edition 
Abstract: Aromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these interactions can be replicated in an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co-assembly experiments with plasmonic gold and surfactant-like peptides (SLPs) spanning a wide range of aromatic residues, polar stretches, and interfacial affinities. The SLPs programmed in DDD−(ZZ)x−FFPC self-assemble into higher-order structures in response to a protease and subsequently modulate the colloidal dispersity of gold leading to a colorimetric readout. Resultsshow the strong aggregation propensity of the FFPC tail without polar DDD head. The SLPs were specific to the target protease, i.e., Mpro, a biomarker for SARS-CoV-2. This system is a simple and visual tool that senses Mproin phosphate buffer, exhaled breath condensate, and saliva with detection limits of 15.7, 20.8, and 26.1 nM, respectively. These results may have value in designing other protease testing methods.
URI: https://hdl.handle.net/10356/163570
ISSN: 1433-7851
DOI: 10.1002/ange.202214394
Schools: School of Materials Science and Engineering 
Organisations: Institute of Materials Research and Engineering, A*STAR 
Rights: © 2022 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. This is the peer reviewed version of the following article: Jin, Z., Li, Y., Li, K., Zhou, J., Yeung, J., Ling, C., Yim, W., He, T., Cheng, Y., Xu, M., Creyer, M. N., Chang, Y., Fajtová, P., Retout, M., Qi, B., Li, S., O'Donoghue, A. J. & Jokerst, J. V. (2022). Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing. Angewandte Chemie International Edition, which has been published in final form at https://doi.org/10.1002/ange.202214394. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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