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|Title:||Reclassifying tumour cell cycle activity in terms of its tissue of origin||Authors:||Lundberg, Arian
Jong, Joan Jing Yi
Lindström, Linda S.
Tobin, Nicholas P.
|Issue Date:||2022||Source:||Lundberg, A., Jong, J. J. Y., Lindström, L. S. & Tobin, N. P. (2022). Reclassifying tumour cell cycle activity in terms of its tissue of origin. NPJ Precision Oncology, 6(1), 59-. https://dx.doi.org/10.1038/s41698-022-00302-7||Journal:||NPJ Precision Oncology||Abstract:||Genomic alterations resulting in loss of control over the cell cycle is a fundamental hallmark of human malignancies. Whilst pan-cancer studies have broadly assessed tumour genomics and their impact on oncogenic pathways, analyses taking the baseline signalling levels in normal tissue into account are lacking. To this end, we aimed to reclassify the cell cycle activity of tumours in terms of their tissue of origin and determine if any common DNA mutations, chromosome arm-level changes or signalling pathways contribute to an increase in baseline corrected cell cycle activity. Combining normal tissue and pan-cancer data from over 13,000 samples we demonstrate that tumours of gynaecological origin show the highest levels of corrected cell cycle activity, partially owing to hormonal signalling and gene expression changes. We also show that normal and tumour tissues can be separated into groups (quadrants) of low/high cell cycle activity and propose the hypothesis of an upper limit on these activity levels in tumours.||URI:||https://hdl.handle.net/10356/163573||ISSN:||2397-768X||DOI:||10.1038/s41698-022-00302-7||Rights:||© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
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