Please use this identifier to cite or link to this item:
Title: Development of SERS tags for human diseases screening and detection
Authors: Gong, Tianxun
Das, Chandreyee Manas
Yin, Ming-Jie
Lv, Tian-Run
Singh, Nishtha Manish
Soehartono, Alana Mauluidy
Singh, Gurvinder
An, Quan-Fu
Yong, Ken-Tye
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2022
Source: Gong, T., Das, C. M., Yin, M., Lv, T., Singh, N. M., Soehartono, A. M., Singh, G., An, Q. & Yong, K. (2022). Development of SERS tags for human diseases screening and detection. Coordination Chemistry Reviews, 470, 214711-.
Journal: Coordination Chemistry Reviews
Abstract: Recent advances in surface-enhanced Raman scattering (SERS) have offered great promise for the early-stage diagnosis of life-threatening diseases by in vivo sensing and imaging techniques as well as a treatment and evaluation of its efficacy. The SERS technique makes use of specially designed tags made up of a metallic nanoparticle, a Raman reporter molecule, a biocompatible protection layer, and a sensing layer, realizing the signal amplification by the electromagnetic enhancement (EE) originating from the plasmon excitation of metal nanostructures and chemical enhancement (CE) owing to chemical interactions and photon-induced charge transfer between the metal and target molecule. These SERS tags have been proven to be a promising candidate for medical applications compared to other conventional techniques because of their high sensitivity, low detection limit, good selectivity, high photostability, low interferences from biological matrices, and multiplexing capabilities. As a result, there has been a surge in the reports for developing SERS tags for molecular diagnostics, immunoassays, biomarker detection, and drug screening applications. Here, we review the recent progress made in the development of SERS tags, including the preparation strategies and properties of SERS tags. The multiple uses of SERS tags in the detection of biomarkers, proteins, cancer and stem cells, cell labeling drug delivery, photothermal therapy, and multimodal imaging techniques have also been reviewed and discussed. Finally, we provide a forward look at how SERS tags may overcome their limitations to guide future SERS tags design with clinical outcomes.
ISSN: 0010-8545
DOI: 10.1016/j.ccr.2022.214711
Schools: School of Electrical and Electronic Engineering 
Rights: © 2022 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:EEE Journal Articles

Citations 20

Updated on Sep 22, 2023

Web of ScienceTM
Citations 20

Updated on Sep 21, 2023

Page view(s)

Updated on Sep 24, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.