Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163646
Title: A systematic review of margin status in retroperitoneal liposarcomas: does the R0 margin matter?
Authors: Paik, Benjamin
Seo, Chin Jin
Tan, Joey Wee-Shan
Juan, Darryl Wen Kai
Soo, Khee Chee
Ong, Johnny Chin-Ann
Chia, Claramae Shulyn
Wong, Jolene Si Min
Keywords: Science::Medicine
Issue Date: 2022
Source: Paik, B., Seo, C. J., Tan, J. W., Juan, D. W. K., Soo, K. C., Ong, J. C., Chia, C. S. & Wong, J. S. M. (2022). A systematic review of margin status in retroperitoneal liposarcomas: does the R0 margin matter?. Frontiers in Oncology, 12, 891710-. https://dx.doi.org/10.3389/fonc.2022.891710
Journal: Frontiers in Oncology 
Abstract: Retroperitoneal liposarcomas (RPLPSs) are a rare tumor group for which current guidelines recommend aggressive en bloc resection to attain microscopically negative (R0) margins. To ensure R0 margins, resection of adherent or adjacent organs is often required. However, it is still unclear if R0 margins confer any additional benefit to patients over a grossly negative but microscopically positive (R1) margin. We performed a systematic search of PubMed and Embase databases for studies including patients receiving R0 or R1 resection for RPLPS. Nine retrospective cohort studies, one prospective cohort study, and 49 case reports/case series were included. A total of 552 patients with RPLPS were evaluated: 346 underwent R0 resection and 206 underwent R1 resection. In the R0 group, 5-year overall survival (OS) ranged from 58.3% to 85.7%; local recurrence (LR) ranged from 45.5% to 52.3%. In the R1 group, 5-year OS ranged from 35% to 55.3%; LR ranged from 66.7% to 91.7%. Among cohort studies, OS, disease-free survival (DFS), LR rate, and LR-free survival (LRFS) were significantly associated with R0 resections. Assessment of case series and reports suggested that the R0 margin led to a slightly higher morbidity than that of R1. In conclusion, this review found the R0 margin to be associated with reductions in LR rates and improved OS when compared with the R1 margins, though accompanied by slight increases in morbidity. The roles of tumor histotype and perioperative chemotherapy or radiotherapy were not well-elucidated in this review.
URI: https://hdl.handle.net/10356/163646
ISSN: 2234-943X
DOI: 10.3389/fonc.2022.891710
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Cancer Centre, Singapore
Singapore General Hospital
Rights: © 2022 Paik, Seo, Tan, Juan, Soo, Ong, Chia and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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