Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163722
Title: Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition
Authors: Zhang, Luoqiang
Zhao, Mengxin
Pu, Maoping
Ma, Zhaoming
Zhou, Jingsong
Chen, Caiyou
Wu, Yun-Dong
Chi, Robin Yonggui
Zhou, Jianrong Steve
Keywords: Science::Chemistry
Issue Date: 2022
Source: Zhang, L., Zhao, M., Pu, M., Ma, Z., Zhou, J., Chen, C., Wu, Y., Chi, R. Y. & Zhou, J. S. (2022). Nickel-catalyzed enantioselective reductive conjugate arylation and heteroarylation via an elementary mechanism of 1,4-addition. Journal of the American Chemical Society, 144(44), 20249-20257. https://dx.doi.org/10.1021/jacs.2c05678
Project: NRF-CRP22-2019-0002
Journal: Journal of the American Chemical Society
Abstract: A nickel complex of isoquinox promoted enantioselective conjugate arylation and heteroarylation of enones using aryl and heteroaryl halides directly. The reaction was successfully applied to stereoselective syntheses of ar-turmerone, chiral fragments of (+)-tolterodine and AZD5672. Mechanistically, experiments and calculations supported that an arylnickel(I) complex inserted to enones via an elementary 1,4-addition.
URI: https://hdl.handle.net/10356/163722
ISSN: 0002-7863
DOI: 10.1021/jacs.2c05678
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2022 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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