Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/163988
Title: Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy
Authors: Yang, Nan
Li, Hui
Cao, Changyu
Zhao, Lei
Song, Xuejiao
Wang, Wenjun
Xu, Wenjing
Zhang, Yewei
Chen, Peng
Dong, Xiaochen
Keywords: Science::Medicine
Issue Date: 2022
Source: Yang, N., Li, H., Cao, C., Zhao, L., Song, X., Wang, W., Xu, W., Zhang, Y., Chen, P. & Dong, X. (2022). Tumor microenvironment-activated theranostic nanoreactor for NIR-II photoacoustic imaging-guided tumor-specific photothermal therapy. Fundamental Research. https://dx.doi.org/10.1016/j.fmre.2022.04.021
Journal: Fundamental Research
Abstract: Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment (TME) have recently attracted considerable attention. In this study, TME-activatable 3,3′,5,5′-tetramethylbenzidine (TMB)-copper peroxide (CuO2)@poly(lactic-co-glycolic acid) (PLGA)@red blood cell membrane (RBCM) (TCPR) nanoparticles (NPs) for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO2 NPs and TMB into PLGA camouflaged by RBCMs. As an efficient H2O2 supplier, once exposed to a proton-rich TME, CuO2 NPs can generate H2O2 and Cu2+, which are further reduced to Cu+ by endogenous glutathione. Subsequently, the Cu+-mediated Fenton-like reaction produces cytotoxic ·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects. Combined with the RBCM modification-prolonged blood circulation, TCPR NPs display excellent specificity and efficiency in suppressing tumor growth, paving the way for more accurate, safe, and efficient cancer theranostics.
URI: https://hdl.handle.net/10356/163988
ISSN: 2096-9457
DOI: 10.1016/j.fmre.2022.04.021
Rights: © 2022 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles

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