Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164052
Title: MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum
Authors: Xiong, Aoli
Kaushal, Simran
Tay, Ian Junjie
Engelward, Bevin P.
Han, Jongyoon
Preiser, Peter Rainer
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Xiong, A., Kaushal, S., Tay, I. J., Engelward, B. P., Han, J. & Preiser, P. R. (2021). MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum. STAR Protocols, 2(3), 100797-. https://dx.doi.org/10.1016/j.xpro.2021.100797
Journal: STAR Protocols
Abstract: Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based on the same principle as the comet assay but provides greater efficacy, automated data processing, and improved consistency between experiments. In this protocol, we present MalariaCometChip to quantitatively assess drug-induced DNA damage in Plasmodium falciparum. For complete details on the use and execution of this protocol, please refer to Xiong et al. (2020).
URI: https://hdl.handle.net/10356/164052
ISSN: 2666-1667
DOI: 10.1016/j.xpro.2021.100797
Schools: School of Biological Sciences 
Organisations: BioSystems and Micromechanics (BioSyM) interdisciplinary research group (IRG), Singapore-MIT Alliance for Research and Technology (SMART)
Anti-Microbial Resistance (AMR) IRG, Singapore-MIT Alliance for Research and Technology (SMART)
Rights: © 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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