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Title: Ultralong floating hydrogel raft for prolonged gastric retention
Authors: Kwang, Guo Dong
Sampathkumar, Kaarunya
Loo, Joachim Say Chye
Keywords: Engineering::Materials::Biomaterials
Engineering::Materials::Functional materials
Issue Date: 2022
Source: Kwang, G. D., Sampathkumar, K. & Loo, J. S. C. (2022). Ultralong floating hydrogel raft for prolonged gastric retention. MRS Bulletin.
Project: MOE/RCE: M4330019.C70 
RT08/19 (S) 
Journal: MRS Bulletin 
Abstract: The optimal therapeutic efficiency of any treatment depends on patient adherence to the medication regimen. Medication adherence is the cornerstone of treatment outcomes that may consequently impact economic and healthcare costs. With the oral route being the preferred route of drug administration, slow or extended-release oral formulations can, therefore, be utilized. Here, a biocompatible oral delivery system that can be retained in the stomach for a week, while providing continuous release of the encased drug, is proposed. The fabrication of the delivery system was achieved using a simple mold casting technique. The hydrogel-based raft was able to float under simulated gastric conditions for seven days with pH switches to mimic the fasted and fed states of the stomach. The functionality of such a delivery system has been exemplified using two different model drugs—risperidone and metoprolol tartrate of varied solubilities and has been shown to effectively sustain the release of drugs under the tested conditions.
ISSN: 0883-7694
DOI: 10.1557/s43577-022-00406-2
Schools: School of Materials Science and Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) 
Rights: © 2022 The Author(s), under exclusive licence to the Materials Research Society. All rights reserved. This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
MSE Journal Articles
SCELSE Journal Articles

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