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Title: Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
Authors: Gu, Xiaoqiong
Sim, Jean X. Y.
Lee, Wei Lin
Cui, Liang
Chan, Yvonne F. Z.
Chang, Ega Danu
Teh, Yii Ean
Zhang, An-Ni
Armas, Federica
Chandra, Franciscus
Chen, Hongjie
Zhao, Shijie
Lee, Zhanyi
Thompson, Janelle
Ooi, Eng Eong
Low, Jenny G.
Alm, Eric J.
Kalimuddin, Shirin
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Gu, X., Sim, J. X. Y., Lee, W. L., Cui, L., Chan, Y. F. Z., Chang, E. D., Teh, Y. E., Zhang, A., Armas, F., Chandra, F., Chen, H., Zhao, S., Lee, Z., Thompson, J., Ooi, E. E., Low, J. G., Alm, E. J. & Kalimuddin, S. (2022). Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea. IScience, 25(1), 103644-.
Project: AM-CT003-2018 
Journal: iScience 
Abstract: Antibiotic-associated diarrhea (AAD) affects a significant proportion of patients receiving antibiotics. We sought to understand if differences in the gut microbiome would influence the development of AAD. We administered a 3-day course of amoxicillin-clavulanate to 30 healthy adult volunteers, and analyzed their stool microbiome, using 16S rRNA gene sequencing, at baseline and up to 4 weeks post antibiotic administration. Lower levels of gut Ruminococcaceae were significantly and consistently observed from baseline until day 7 in participants who developed AAD. Overall, participants who developed AAD experienced a greater decrease in microbial diversity. The probability of AAD could be predicted based on qPCR-derived levels of Faecalibacterium prausnitzii at baseline. Our findings suggest that a lack of gut Ruminococcaceae influences development of AAD. Quantification of F. prausnitzii in stool prior to antibiotic administration may help identify patients at risk of AAD, and aid clinicians in devising individualized treatment regimens to minimize such adverse effects.
ISSN: 2589-0042
DOI: 10.1016/j.isci.2021.103644
Rights: © 2021 The Author(s). This is an open access article under the CC BY license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:ASE Journal Articles
SCELSE Journal Articles

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