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Title: Cerium oxide nanoparticles with entrapped gadolinium for high T₁ relaxivity and ROS-scavenging purposes
Authors: Eriksson, Peter
Truong, Anh H. T.
Brommesson, Caroline
du Rietz, Anna
Kokil, Ganesh R.
Boyd, Robert D.
Hu, Zhangjun
Dang, Tram T.
Persson, Per O. A.
Uvdal, Kajsa
Keywords: Engineering::Chemical engineering
Issue Date: 2022
Source: Eriksson, P., Truong, A. H. T., Brommesson, C., du Rietz, A., Kokil, G. R., Boyd, R. D., Hu, Z., Dang, T. T., Persson, P. O. A. & Uvdal, K. (2022). Cerium oxide nanoparticles with entrapped gadolinium for high T₁ relaxivity and ROS-scavenging purposes. ACS Omega, 7(24), 21337-21345.
Journal: ACS Omega 
Abstract: Gadolinium chelates are employed worldwide today as clinical contrast agents for magnetic resonance imaging. Until now, the commonly used linear contrast agents based on the rare-earth element gadolinium have been considered safe and well-tolerated. Recently, concerns regarding this type of contrast agent have been reported, which is why there is an urgent need to develop the next generation of stable contrast agents with enhanced spin-lattice relaxation, as measured by improved T 1 relaxivity at lower doses. Here, we show that by the integration of gadolinium ions in cerium oxide nanoparticles, a stable crystalline 5 nm sized nanoparticulate system with a homogeneous gadolinium ion distribution is obtained. These cerium oxide nanoparticles with entrapped gadolinium deliver strong T 1 relaxivity per gadolinium ion (T 1 relaxivity, r 1 = 12.0 mM-1 s-1) with the potential to act as scavengers of reactive oxygen species (ROS). The presence of Ce3+ sites and oxygen vacancies at the surface plays a critical role in providing the antioxidant properties. The characterization of radial distribution of Ce3+ and Ce4+ oxidation states indicated a higher concentration of Ce3+ at the nanoparticle surfaces. Additionally, we investigated the ROS-scavenging capabilities of pure gadolinium-containing cerium oxide nanoparticles by bioluminescent imaging in vivo, where inhibitory effects on ROS activity are shown.
ISSN: 2470-1343
DOI: 10.1021/acsomega.2c03055
Schools: School of Chemical and Biomedical Engineering 
Research Centres: Laboratory of Therapeutic Cellular and Drug Delivery Systems
Rights: © 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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