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Title: Bone bricks: the effect of architecture and material composition on the mechanical and biological performance of bone scaffolds
Authors: Daskalakis, Evangelos
Huang, Boyang
Vyas, Cian
Acar, Anil A.
Liu, Fengyuan
Fallah, Ali
Cooper, Glen
Weightman, Andrew
Blunn, Gordon
Koç, Bahattin
Bartolo, Paulo
Keywords: Engineering::Mechanical engineering
Issue Date: 2022
Source: Daskalakis, E., Huang, B., Vyas, C., Acar, A. A., Liu, F., Fallah, A., Cooper, G., Weightman, A., Blunn, G., Koç, B. & Bartolo, P. (2022). Bone bricks: the effect of architecture and material composition on the mechanical and biological performance of bone scaffolds. ACS Omega, 7(9), 7515-7530.
Journal: ACS Omega 
Abstract: Large bone loss injuries require high-performance scaffolds with an architecture and material composition resembling native bone. However, most bone scaffold studies focus on three-dimensional (3D) structures with simple rectangular or circular geometries and uniform pores, not able to recapitulate the geometric characteristics of the native tissue. This paper addresses this limitation by proposing novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions (pore size gradients) designed based on new lay-dawn pattern strategies. The gradient design allows one to tailor the properties of the bricks and together with the incorporation of ceramic materials allows one to obtain structures with high mechanical properties (higher than reported in the literature for the same material composition) and improved biological characteristics.
ISSN: 2470-1343
DOI: 10.1021/acsomega.1c05437
Schools: School of Mechanical and Aerospace Engineering 
Research Centres: Singapore Centre for 3D Printing 
Rights: © 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
SC3DP Journal Articles

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