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Title: Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters
Authors: Rouers, Angeline
Wong, Nathan
Goh, Yun Shan
Torres-Ruesta, Anthony
Tay, Matthew Zirui
Chang, Zi Wei
Fong, Siew-Wai
Neo, Vanessa
Kam, Isaac Kai Jie
Yeo, Nicholas Kim-Wah
Huang, Yuling
Loh, Chiew Yee
Hor, Pei Xiang
Wong, Joel Xu En
Tan, Yong Jie
Macary, Paul A.
Qian, Xinlei
Bei, Wang
Ngoh, Eve Zi Xian
Salleh, Siti Nazihah Mohd
Wang, Cheng-I
Poh, Xuan Ying
Rao, Suma
Chia, Po Ying
Ong, Sean W. X.
Lee, Tau Hong
Lin, Ray J. H.
Lim, Clarissa
Teo, Jefanie
Ren, Ee Chee
Lye, David C.
Young, Barnaby Edward
Ng, Lisa F. P.
Renia, Laurent
Keywords: Science::Medicine
Issue Date: 2023
Source: Rouers, A., Wong, N., Goh, Y. S., Torres-Ruesta, A., Tay, M. Z., Chang, Z. W., Fong, S., Neo, V., Kam, I. K. J., Yeo, N. K., Huang, Y., Loh, C. Y., Hor, P. X., Wong, J. X. E., Tan, Y. J., Macary, P. A., Qian, X., Bei, W., Ngoh, E. Z. X., ...Renia, L. (2023). Efficient recall of SARS-CoV-2 variant-reactive B cells and T responses in the elderly upon heterologous mRNA vaccines as boosters. Journal of Medical Virology, 95(1), e28258-.
Project: ACCL/19‐GAP064‐R20H‐H 
Journal: Journal of Medical Virology 
Abstract: Waning antibody levels against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants of concern highlight the need for booster vaccinations. This is particularly important for the elderly population, who are at a higher risk of developing severe coronavirus disease 2019 (COVID-19) disease. While studies have shown increased antibody responses following booster vaccination, understanding the changes in T and B cell compartments induced by a third vaccine dose remains limited. We analyzed the humoral and cellular responses in subjects who received either a homologous messenger RNA(mRNA) booster vaccine (BNT162b2 + BNT162b2 + BNT162b2; ''BBB") or a heterologous mRNA booster vaccine (BNT162b2 + BNT162b2 + mRNA-1273; ''BBM") at Day 0 (prebooster), Day 7, and Day 28 (postbooster). Compared with BBB, elderly individuals (≥60 years old) who received the BBM vaccination regimen display higher levels of neutralizing antibodies against the Wuhan and Delta strains along with a higher boost in immunoglobulin G memory B cells, particularly against the Omicron variant. Circulating T helper type 1(Th1), Th2, Th17, and T follicular helper responses were also increased in elderly individuals given the BBM regimen. While mRNA vaccines increase antibody, T cell, and B cell responses against SARS-CoV-2 1 month after receiving the third dose booster, the efficacy of the booster vaccine strategies may vary depending on age group and regimen combination.
ISSN: 0146-6615
DOI: 10.1002/jmv.28258
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: National Centre for Infectious Diseases
Tan Tock Seng Hospital
A*STAR Infectious Diseases Labs
Rights: © 2022 Wiley Periodicals LLC. All rights reserved. This is the peer reviewed version of the following article: Rouers A, Wong N, Goh YS, et al. Efficient recall of SARS‐CoV‐2 variant‐reactive B cells and Tresponses in the elderly upon heterologous mRNA vaccines asboosters. Journal of Medical Virology, 95(1), e28258, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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