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Title: Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones
Authors: Santoso, Mardi
Ong, Li Lin
Aijijiyah, Nur Pasca
Wati, First Ambar
Azminah, Azminah
Annuur, Rose Malina
Fadlan, Arif
Judeh, Zaher M. A.
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Santoso, M., Ong, L. L., Aijijiyah, N. P., Wati, F. A., Azminah, A., Annuur, R. M., Fadlan, A. & Judeh, Z. M. A. (2022). Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones. Heliyon, 8(3), e09045-.
Project: RG142/16
Journal: Heliyon
Abstract: The synthesized 3,3-di(indolyl)indolin-2-ones 1a-p showed desired higher α-glucosidase inhibitory activities and lower α-amylase inhibitory activities than standard drug acarbose. Particularly, compound 1i showed favorable higher α-glucosidase % inhibition of 67 ± 13 and lower α-amylase % inhibition of 51 ± 4 in comparison to acarbose with % inhibition activities of 19 ± 5 and 90 ± 2, respectively. Docking studies of selected 3,3-di(indolyl)indolin-2-ones revealed key interactions with the active sites of both α-glucosidase and α-amylase, further supporting the observed % inhibitory activities. Furthermore, the binding energies are consistent with the % inhibition values. The results suggest that 3,3-di(indolyl)indolin-2-ones may be developed as suitable Alpha Glucosidase Inhibitors (AGIs) and the lower α-amylase activities should be advantageous to reduce the side effects exhibited by commercial AGIs.
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2022.e09045
Schools: Interdisciplinary Graduate School (IGS) 
School of Chemical and Biomedical Engineering 
School of Physical and Mathematical Sciences 
Research Centres: NTU Institute for Health Technologies 
Rights: © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
SCBE Journal Articles
SPMS Journal Articles

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