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Title: Pre-arranged building block approach for the orthogonal synthesis of an unfolded tetrameric organic–inorganic phosphazane macrocycle
Authors: Sim, Ying
Leon, Felix
Hum, Gavin
Phang, Isabel Si Jia
Ong, How Chee
Ganguly, Rakesh
Díaz, Jesús
Clegg, Jack K.
García, Felipe
Keywords: Science::Chemistry
Issue Date: 2022
Source: Sim, Y., Leon, F., Hum, G., Phang, I. S. J., Ong, H. C., Ganguly, R., Díaz, J., Clegg, J. K. & García, F. (2022). Pre-arranged building block approach for the orthogonal synthesis of an unfolded tetrameric organic–inorganic phosphazane macrocycle. Communications Chemistry, 5(1), 59-1-59-9.
Project: A1783c0003
Journal: Communications Chemistry
Abstract: Inorganic macrocycles remain challenging synthetic targets due to the limited number of strategies reported for their syntheses. Among these species, large fully inorganic cyclodiphosphazane macrocycles have been experimentally and theoretically highlighted as promising candidates for supramolecular chemistry. In contrast, their hybrid organic–inorganic counterparts are lagging behind due to the lack of synthetic routes capable of controlling the size and topological arrangement (i.e., folded vs unfolded) of the target macrocycle, rendering the synthesis of differently sized macrocycles a tedious screening process. Herein, we report—as a proof-of-concept—the combination of pre-arranged building blocks and a two-step synthetic route to rationally enable access a large unfolded tetrameric macrocycle, which is not accessible via conventional synthetic strategies. The obtained macrocycle hybrid cyclodiphosphazane macrocycle, cis-[μ-P(μ-NtBu)]2(μ-p-OC6H4C(O)O)]4[μ-P(μ-NtBu)]2 (4), displays an unfolded open-face cavity area of 110.1 Å2. Preliminary theoretical host–guest studies with the dication [MeNC5H4]22+ suggest compound 4 as a viable candidate for the synthesis of hybrid proto-rotaxanes species based on phosphazane building blocks.
ISSN: 2399-3669
DOI: 10.1038/s42004-022-00673-9
Schools: School of Physical and Mathematical Sciences 
Rights: © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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