Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164332
Title: Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Authors: Winkler, Thomas W.
Rasheed, Humaira
Teumer, Alexander
Gorski, Mathias
Rowan, Bryce X.
Stanzick, Kira J.
Thomas, Laurent F.
Tin, Adrienne
Hoppmann, Anselm
Chu, Audrey Y.
Tayo, Bamidele
Thio, Chris H. L.
Cusi, Daniele
Chai, Jin-Fang
Sieber, Karsten B.
Horn, Katrin
Li, Man
Scholz, Markus
Cocca, Massimiliano
Wuttke, Matthias
van der Most, Peter J.
Yang, Qiong
Ghasemi, Sahar
Nutile, Teresa
Li, Yong
Pontali, Giulia
Günther, Felix
Dehghan, Abbas
Correa, Adolfo
Parsa, Afshin
Feresin, Agnese
de Vries, Aiko P. J.
Zonderman, Alan B.
Smith, Albert V.
Oldehinkel, Albertine J.
De Grandi, Alessandro
Rosenkranz, Alexander R.
Franke, Andre
Teren, Andrej
Metspalu, Andres
Hicks, Andrew A.
Morris, Andrew P.
Tönjes, Anke
Morgan, Anna
Podgornaia, Anna I.
Peters, Annette
Körner, Antje
Mahajan, Anubha
Campbell, Archie
Freedman, Barry I.
Spedicati, Beatrice
Ponte, Belen
Schöttker, Ben
Brumpton, Ben
Banas, Bernhard
Krämer, Bernhard K.
Jung, Bettina
Åsvold, Bjørn Olav
Smith, Blair H.
Ning, Boting
Penninx, Brenda W. J. H.
Vanderwerff, Brett R.
Psaty, Bruce M.
Kammerer, Candace M.
Langefeld, Carl D.
Hayward, Caroline
Spracklen, Cassandra N.
Robinson-Cohen, Cassianne
Hartman, Catharina A.
Lindgren, Cecilia M.
Wang, Chaolong
Sabanayagam, Charumathi
Heng, Chew-Kiat
Lanzani, Chiara
Khor, Chiea-Chuen
Cheng, Ching-Yu
Fuchsberger, Christian
Gieger, Christian
Shaffer, Christian M.
Schulz, Christina-Alexandra
Willer, Cristen J.
Chasman, Daniel I.
Gudbjartsson, Daniel F.
Ruggiero, Daniela
Toniolo, Daniela
Czamara, Darina
Porteous, David J.
Waterworth, Dawn M.
Mascalzoni, Deborah
Mook-Kanamori, Dennis O.
Reilly, Dermot F.
Daw, E Warwick
Hofer, Edith
Boerwinkle, Eric
Salvi, Erika
Bottinger, Erwin P.
Tai, E-Shyong
Catamo, Eulalia
Rizzi, Federica
Guo, Feng
Rivadeneira, Fernando
Guilianini, Franco
Sveinbjornsson, Gardar
Ehret, Georg
Waeber, Gerard
Biino, Ginevra
Girotto, Giorgia
Pistis, Giorgio
Nadkarni, Girish N.
Delgado, Graciela E.
Montgomery, Grant W.
Snieder, Harold
Campbell, Harry
White, Harvey D.
Gao, He
Stringham, Heather M.
Schmidt, Helena
Li, Hengtong
Brenner, Hermann
Holm, Hilma
Kirsten, Holgen
Kramer, Holly
Rudan, Igor
Nolte, Ilja M.
Tzoulaki, Ioanna
Olafsson, Isleifur
Martins, Jade
Cook, James P.
Wilson, James F.
Halbritter, Jan
Felix, Janine F.
Divers, Jasmin
Kooner, Jaspal S.
Lee, Jeannette Jen-Mai
O'Connell, Jeffrey
Rotter, Jerome I.
Liu, Jianjun
Xu, Jie
Thiery, Joachim
Ärnlöv, Johan
Kuusisto, Johanna
Jakobsdottir, Johanna
Tremblay, Johanne
Chambers, John Campbell
Whitfield, John B.
Gaziano, John M.
Marten, Jonathan
Coresh, Josef
Jonas, Jost B.
Mychaleckyj, Josyf C.
Christensen, Kaare
Eckardt, Kai-Uwe
Mohlke, Karen L.
Endlich, Karlhans
Dittrich, Katalin
Ryan, Kathleen A.
Rice, Kenneth M.
Taylor, Kent D.
Ho, Kevin
Nikus, Kjell
Matsuda, Koichi
Strauch, Konstantin
Miliku, Kozeta
Hveem, Kristian
Lind, Lars
Wallentin, Lars
Yerges-Armstrong, Laura M.
Raffield, Laura M.
Phillips, Lawrence S.
Launer, Lenore J.
Lyytikäinen, Leo-Pekka
Lange, Leslie A.
Citterio, Lorena
Klaric, Lucija
Ikram, M Arfan
Ising, Marcus
Kleber, Marcus E.
Francescatto, Margherita
Concas, Maria Pina
Ciullo, Marina
Piratsu, Mario
Orho-Melander, Marju
Laakso, Markku
Loeffler, Markus
Perola, Markus
de Borst, Martin H.
Gögele, Martin
Bianca, Martina La
Lukas, Mary Ann
Feitosa, Mary F.
Biggs, Mary L.
Wojczynski, Mary K.
Kavousi, Maryam
Kanai, Masahiro
Akiyama, Masato
Yasuda, Masayuki
Nauck, Matthias
Waldenberger, Melanie
Chee, Miao-Li
Chee, Miao-Ling
Boehnke, Michael
Preuss, Michael H.
Stumvoll, Michael
Province, Michael A.
Evans, Michele K.
O'Donoghue, Michelle L.
Kubo, Michiaki
Kähönen, Mika
Kastarinen, Mika
Nalls, Mike A.
Kuokkanen, Mikko
Ghanbari, Mohsen
Bochud, Murielle
Josyula, Navya Shilpa
Martin, Nicholas G.
Tan, Nicholas Y. Q.
Palmer, Nicholette D.
Pirastu, Nicola
Schupf, Nicole
Verweij, Niek
Hutri-Kähönen, Nina
Mononen, Nina
Bansal, Nisha
Devuyst, Olivier
Melander, Olle
Raitakari, Olli T.
Polasek, Ozren
Manunta, Paolo
Gasparini, Paolo
Mishra, Pashupati P.
Sulem, Patrick
Magnusson, Patrik K. E.
Elliott, Paul
Ridker, Paul M.
Hamet, Pavel
Svensson, Per O.
Joshi, Peter K.
Kovacs, Peter
Pramstaller, Peter P.
Rossing, Peter
Vollenweider, Peter
van der Harst, Pim
Dorajoo, Rajkumar
Sim, Ralene Z. H.
Burkhardt, Ralph
Tao, Ran
Noordam, Raymond
Mägi, Reedik
Schmidt, Reinhold
de Mutsert, Renée
Rueedi, Rico
van Dam, Rob M.
Carroll, Robert J.
Gansevoort, Ron T.
Loos, Ruth J. F.
Felicita, Sala Cinzia
Sedaghat, Sanaz
Padmanabhan, Sandosh
Freitag-Wolf, Sandra
Pendergrass, Sarah A.
Graham, Sarah E.
Gordon, Scott D.
Hwang, Shih-Jen
Kerr, Shona M.
Vaccargiu, Simona
Patil, Snehal B.
Hallan, Stein
Bakker, Stephan J. L.
Lim, Su-Chi
Lucae, Susanne
Vogelezang, Suzanne
Bergmann, Sven
Corre, Tanguy
Ahluwalia, Tarunveer S.
Lehtimäki, Terho
Boutin, Thibaud S.
Meitinger, Thomas
Wong, Tien-Yin
Bergler, Tobias
Rabelink, Ton J.
Esko, Tõnu
Haller, Toomas
Thorsteinsdottir, Unnur
Völker, Uwe
Foo, Valencia Hui Xian
Salomaa, Veikko
Vitart, Veronique
Giedraitis, Vilmantas
Gudnason, Vilmundur
Jaddoe, Vincent W. V.
Huang, Wei
Zhang, Weihua
Wei, Wen Bin
Kiess, Wieland
März, Winfried
Koenig, Wolfgang
Lieb, Wolfgang
Gao, Xin
Sim, Xueling
Wang, Ya Xing
Friedlander, Yechiel
Tham, Yih-Chung
Kamatani, Yoichiro
Okada, Yukinori
Milaneschi, Yuri
Yu, Zhi
Stark, Klaus J.
Stefansson, Kari
Böger, Carsten A.
Hung, Adriana M.
Kronenberg, Florian
Köttgen, Anna
Pattaro, Cristian
Heid, Iris M.
Thio, Chris H. L.
van der Most, Peter J.
de Borst, Martin H.
Ho, Kevin
Josyula, Navya Shilpa
Pendergrass, Sarah A.
Rowan, Bryce X.
Robinson-Cohen, Cassianne
Gaziano, John M.
Phillips, Lawrence S.
Tao, Ran
Hung, Adriana M.
Keywords: Science::Medicine
Issue Date: 2022
Source: Winkler, T. W., Rasheed, H., Teumer, A., Gorski, M., Rowan, B. X., Stanzick, K. J., Thomas, L. F., Tin, A., Hoppmann, A., Chu, A. Y., Tayo, B., Thio, C. H. L., Cusi, D., Chai, J., Sieber, K. B., Horn, K., Li, M., Scholz, M., Cocca, M., ...Hung, A. M. (2022). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 5(1), 1-20. https://dx.doi.org/10.1038/s42003-022-03448-z
Journal: Communications Biology 
Abstract: Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
URI: https://hdl.handle.net/10356/164332
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03448-z
Rights: © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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