Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164358
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNgo, Khac Huyen_US
dc.date.accessioned2023-01-17T07:51:19Z-
dc.date.available2023-01-17T07:51:19Z-
dc.date.issued2022-
dc.identifier.citationNgo, K. H. (2022). Structure and protein recognition of G-quadruplexes. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/164358en_US
dc.identifier.urihttps://hdl.handle.net/10356/164358-
dc.description.abstractG-rich oligonucleotides can adopt non-canonical secondary structures called G-quadruplexes (G4s) which are biologically relevant and found in applications and nanotechnology. Due to the high structural polymorphism, it is still a challenge to specifically target different G4 structures. In this study, different biophysical, biochemical, and structural techniques (CD, ITC, gel electrophoresis, enzymatic assay NMR spectroscopy, X-ray crystallography) and nucleic acid/protein/peptide engineering were applied to: i) expand our understanding of G4 diversity including base stacking, interlocking, and A•G•G•G•G pentad formation; ii) study the molecular basis for G4 recognition by proteins; iii) engineer G4-binding proteins/peptides for various applications including stable cyclic peptide or engineered enzyme for G4s targeting. The findings from this study provide a better understanding of G4 structures and their recognition by proteins.en_US
dc.language.isoenen_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.subjectScience::Physicsen_US
dc.titleStructure and protein recognition of G-quadruplexesen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorPhan Anh Tuanen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.degreeDoctor of Philosophyen_US
dc.identifier.doi10.32657/10356/164358-
dc.contributor.supervisoremailPhanTuan@ntu.edu.sgen_US
item.grantfulltextembargo_20250117-
item.fulltextWith Fulltext-
Appears in Collections:SPMS Theses
Files in This Item:
File Description SizeFormat 
Final_Thesis_Huy_(v20).pdf
  Until 2025-01-17
45.88 MBAdobe PDFUnder embargo until Jan 17, 2025

Page view(s)

201
Updated on May 22, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.