Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164367
Title: Transitional premonocytes emerge in the periphery for host defense against bacterial infections
Authors: Teh, Ye Chean
Chooi, Ming Yao
Liu, Dehua
Kwok, Immanuel
Lai, Ghee Chuan
Ow Yong, Liyana Ayub
Ng, Melissa
Li, Jackson L. Y.
Tan, Yingrou
Evrard, Maximilien
Tan, Leonard
Liong, Ka Hang
Leong, Keith
Goh, Chi Ching
Chan, Andrew Y. J.
Nurhidaya Binte Shadan
Mantri, Chinmay Kumar
Hwang, You Yi
Cheng, Hui
Cheng, Tao
Yu, Weimiao
Tey, Hong Liang
Larbi, Anis
St John, Ashley
Angeli, Veronique
Ruedl, Christiane
Lee, Bernett
Ginhoux, Florent
Chen, Swaine L.
Ng, Lai Guan
Ding, Jeak Ling
Chong, Shu Zhen
Keywords: Science::Medicine
Science::Biological sciences
Issue Date: 2022
Source: Teh, Y. C., Chooi, M. Y., Liu, D., Kwok, I., Lai, G. C., Ow Yong, L. A., Ng, M., Li, J. L. Y., Tan, Y., Evrard, M., Tan, L., Liong, K. H., Leong, K., Goh, C. C., Chan, A. Y. J., Nurhidaya Binte Shadan, Mantri, C. K., Hwang, Y. Y., Cheng, H., ...Chong, S. Z. (2022). Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Science Advances, 8(9), eabj4641-. https://dx.doi.org/10.1126/sciadv.abj4641
Project: NRF2017_SISFP09
Journal: Science Advances
Abstract: Circulating Ly6Chi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during bacterial invasion to avert infection morbidity. Here, we show that proliferating transitional premonocytes (TpMos), an immediate precursor of mature Ly6Chi monocytes (MatMos), were mobilized into the periphery in response to acute bacterial infection and sepsis. TpMos were less susceptible to apoptosis and served as the main source of macrophage replenishment when MatMos were vulnerable toward bacteria-induced cellular death. Furthermore, TpMo and its derived macrophages contributed to host defense by balancing the proinflammatory cytokine response of MatMos. Consequently, adoptive transfer of TpMos improved the survival outcome of lethal sepsis. Our findings hence highlight a protective role for TpMos during bacterial infections and their contribution toward monocyte-derived macrophage heterogeneity in distinct disease outcomes.
URI: https://hdl.handle.net/10356/164367
ISSN: 2375-2548
DOI: 10.1126/sciadv.abj4641
Rights: © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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