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Title: Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Authors: Personnaz, Jean
Piccolo, Enzo
Dortignac, Alizée
Iacovoni, Jason S.
Mariette, Jérôme
Rocher, Vincent
Polizzi, Arnaud
Batut, Aurélie
Deleruyelle, Simon
Bourdens, Lucas
Delos, Océane
Combes-Soia, Lucie
Paccoud, Romain
Moreau, Elsa
Martins, Frédéric
Clouaire, Thomas
Benhamed, Fadila
Montagner, Alexandra
Wahli, Walter
Schwabe, Robert F.
Yart, Armelle
Castan-Laurell, Isabelle
Bertrand-Michel, Justine
Burlet-Schiltz, Odile
Postic, Catherine
Denechaud, Pierre-Damien
Moro, Cédric
Legube, Gaelle
Lee, Chih-Hao
Guillou, Hervé
Valet, Philippe
Dray, Cédric
Pradère, Jean-Philippe
Keywords: Science::Medicine
Issue Date: 2022
Source: Personnaz, J., Piccolo, E., Dortignac, A., Iacovoni, J. S., Mariette, J., Rocher, V., Polizzi, A., Batut, A., Deleruyelle, S., Bourdens, L., Delos, O., Combes-Soia, L., Paccoud, R., Moreau, E., Martins, F., Clouaire, T., Benhamed, F., Montagner, A., Wahli, W., ...Pradère, J. (2022). Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. Science Advances, 8(12), eabg9055-.
Journal: Science Advances 
Abstract: Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis are very complex and fine-tuned by chromatin dynamics and multiple key transcription factors. Here, we demonstrate that the nuclear factor HMGB1 acts as a strong repressor of liver lipogenesis. Mice with liver-specific Hmgb1 deficiency display exacerbated liver steatosis, while Hmgb1-overexpressing mice exhibited a protection from fatty liver progression when subjected to nutritional stress. Global transcriptome and functional analysis revealed that the deletion of Hmgb1 gene enhances LXRα and PPARγ activity. HMGB1 repression is not mediated through nucleosome landscape reorganization but rather via a preferential DNA occupation in a region carrying genes regulated by LXRα and PPARγ. Together, these findings suggest that hepatocellular HMGB1 protects from liver steatosis development. HMGB1 may constitute a new attractive option to therapeutically target the LXRα-PPARγ axis during NAFLD.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abg9055
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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