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Title: A wireless and battery-free wound infection sensor based on DNA hydrogel
Authors: Xiong, Ze
Achavananthadith, Sippanat
Lian, Sophie
Madden, Leigh Edward
Ong, Zi Xin
Chua, Wisely
Kalidasan, Viveka
Li, Zhipeng
Liu, Zhu
Singh, Priti
Yang, Haitao
Heussler, Sascha P.
Kalaiselvi, S. M. P.
Breese, Mark B. H.
Yao, Haicheng
Gao, Yuji
Sanmugam, Kavitha
Tee, Benjamin C. K.
Chen, Po-Yen
Loke, Weiqiang
Lim, Chwee Teck
Chiang, Grace Shu Hui
Tan, Boon Yeow
Li, Hao
Becker, David Laurence
Ho, John S.
Keywords: Science::Medicine
Issue Date: 2021
Source: Xiong, Z., Achavananthadith, S., Lian, S., Madden, L. E., Ong, Z. X., Chua, W., Kalidasan, V., Li, Z., Liu, Z., Singh, P., Yang, H., Heussler, S. P., Kalaiselvi, S. M. P., Breese, M. B. H., Yao, H., Gao, Y., Sanmugam, K., Tee, B. C. K., Chen, P., ...Ho, J. S. (2021). A wireless and battery-free wound infection sensor based on DNA hydrogel. Science Advances, 7(47), eabj1617-.
Project: H17/01/a0/0C9 
Journal: Science Advances 
Abstract: The confluence of wireless technology and biosensors offers the possibility to detect and manage medical conditions outside of clinical settings. Wound infections represent a major clinical challenge in which timely detection is critical for effective interventions, but this is currently hindered by the lack of a monitoring technology that can interface with wounds, detect pathogenic bacteria, and wirelessly transmit data. Here, we report a flexible, wireless, and battery-free sensor that provides smartphone-based detection of wound infection using a bacteria-responsive DNA hydrogel. The engineered DNA hydrogels respond selectively to deoxyribonucleases associated with pathogenic bacteria through tunable dielectric changes, which can be wirelessly detected using near-field communication. In a mouse acute wound model, we demonstrate that the wireless sensor can detect physiologically relevant amounts of Staphylococcus aureus even before visible manifestation of infection. These results demonstrate strategies for continuous infection monitoring, which may facilitate improved management of surgical or chronic wounds.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abj1617
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Interdisciplinary Graduate School (IGS) 
Organisations: Skin Research Institute of Singapore
Department of Chemistry, NUS
Rights: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles

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