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Title: Ball-milled graphene quantum dots for enhanced anti-cancer drug delivery
Authors: Prabhakar, Arun Kumar
Ajith, M.P.
Ananthanarayanan, Arundithi
Routh, Parimal
Mohan, Babu Cadiam
Thamizhchelvan, Anbu Mozhi
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Prabhakar, A. K., Ajith, M., Ananthanarayanan, A., Routh, P., Mohan, B. C. & Thamizhchelvan, A. M. (2022). Ball-milled graphene quantum dots for enhanced anti-cancer drug delivery. OpenNano, 8, 100072-.
Project: MOE2011-T2–2–010
Journal: OpenNano
Abstract: Graphene quantum dots (GQDs) exhibit excellent opto-electronic properties along with fine-tunable structure and surface properties, which have made them versatile drug carriers. Here GQDs were prepared using carbon black as precursor through oxidation and ball-milling. The prepared GQDs were found to be nano-sized, oxidized, water-soluble and highly fluorescent. The GQDs were found to be extremely biocompatible against the tested cell lines namely: LO2, HeLa, PC-12 and MCF-7 and uptaken by cancer cells in greater amounts with increased concentrations and incubation times. B-Lapachone, an anti-cancer hydrophobic drug, was loaded onto the GQDs through pi-pi bonding and tested for its release profile through dialysis. The drug was released at a significantly higher rate at acidic pH specifically, to cancer cells as compared to the normal cell's relative alkaline pH. The GQD-drug conjugate was found to exhibit enhanced cytotoxicity in cancer cell lines relative to free drug from MTT assay. In whole, sized-down GQDs, having excellent biocompatibility and photostability with enhanced drug delivery properties has been designed and tested.
ISSN: 2352-9520
DOI: 10.1016/j.onano.2022.100072
Rights: © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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