Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164428
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dc.contributor.authorPitt, Daviden_US
dc.contributor.authorLo, Chih Hungen_US
dc.contributor.authorGauthier, Susan A.en_US
dc.contributor.authorHickman, Richard A.en_US
dc.contributor.authorLongbrake, Erinen_US
dc.contributor.authorAiras, Laura M.en_US
dc.contributor.authorMao-Draayer, Yangen_US
dc.contributor.authorRiley, Claireen_US
dc.contributor.authorDe Jager, Philip Lawrenceen_US
dc.contributor.authorWesley, Sarahen_US
dc.contributor.authorBoster, Aaronen_US
dc.contributor.authorTopalli, Iliren_US
dc.contributor.authorBagnato, Francescaen_US
dc.contributor.authorMansoor, Mohammaden_US
dc.contributor.authorStuve, Olafen_US
dc.contributor.authorKister, Ilyaen_US
dc.contributor.authorPelletier, Danielen_US
dc.contributor.authorStathopoulos, Panosen_US
dc.contributor.authorDutta, Ranjanen_US
dc.contributor.authorLincoln, Matthew R.en_US
dc.date.accessioned2023-01-25T01:06:41Z-
dc.date.available2023-01-25T01:06:41Z-
dc.date.issued2022-
dc.identifier.citationPitt, D., Lo, C. H., Gauthier, S. A., Hickman, R. A., Longbrake, E., Airas, L. M., Mao-Draayer, Y., Riley, C., De Jager, P. L., Wesley, S., Boster, A., Topalli, I., Bagnato, F., Mansoor, M., Stuve, O., Kister, I., Pelletier, D., Stathopoulos, P., Dutta, R. & Lincoln, M. R. (2022). Toward precision phenotyping of multiple sclerosis. Neurology® Neuroimmunology & Neuroinflammation, 9(6), e200025-. https://dx.doi.org/10.1212/NXI.0000000000200025en_US
dc.identifier.issn2332-7812en_US
dc.identifier.urihttps://hdl.handle.net/10356/164428-
dc.description.abstractThe classification of multiple sclerosis (MS) has been established by Lublin in 1996 and revised in 2013. The revision includes clinically isolated syndrome, relapsing-remitting, primary progressive and secondary progressive MS, and has added activity (i.e., formation of white matter lesions or clinical relapses) as a qualifier. This allows for the distinction between active and nonactive progression, which has been shown to be of clinical importance. We propose that a logical extension of this classification is the incorporation of additional key pathological processes, such as chronic perilesional inflammation, neuroaxonal degeneration, and remyelination. This will distinguish MS phenotypes that may present as clinically identical but are driven by different combinations of pathological processes. A more precise description of MS phenotypes will improve prognostication and personalized care as well as clinical trial design. Thus, our proposal provides an expanded framework for conceptualizing MS and for guiding development of biomarkers for monitoring activity along the main pathological axes in MS.en_US
dc.language.isoenen_US
dc.relation.ispartofNeurology® Neuroimmunology & Neuroinflammationen_US
dc.rights© 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.en_US
dc.subjectScience::Medicineen_US
dc.titleToward precision phenotyping of multiple sclerosisen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1212/NXI.0000000000200025-
dc.description.versionPublished versionen_US
dc.identifier.pmid36041861-
dc.identifier.scopus2-s2.0-85136992193-
dc.identifier.issue6en_US
dc.identifier.volume9en_US
dc.identifier.spagee200025en_US
dc.subject.keywordsMultiple Sclerosisen_US
dc.subject.keywordsNeurologic Diseaseen_US
dc.description.acknowledgementStudy Funding: Supported in part by NIH grants R01 NS102267 and R01 NS112907 (D.P.) and a career transition fellowship from the Consortium of Multiple Sclerosis Centers and the National Multiple Sclerosis Society (M.R.L.). The Article Processing Charge was funded by the authors.en_US
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