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Title: State-of-the-art self-luminescence: a win-win situation
Authors: Yang, Mingwang
Zeng, Ziling
Lam, Jacky W. Y.
Fan, Jiangli
Pu, Kanyi
Tang, Ben Zhong
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Yang, M., Zeng, Z., Lam, J. W. Y., Fan, J., Pu, K. & Tang, B. Z. (2022). State-of-the-art self-luminescence: a win-win situation. Chemical Society Reviews, 51(21), 8815-8831.
Journal: Chemical Society reviews
Abstract: Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity in bioassay. Furthermore, in situ generated and emitted photons have been applied to develop excitation-free diagnostics and therapeutic agents against deeply seated diseases. "Enhanced" self-luminescence, referring to the aggregation-induced emission (AIE)-integrated self-luminescence systems, is endowed with not only the above merits but also other superiorities including stronger luminous brightness and longer half-life compared with "traditional" self-luminescence platforms. As an emerging and booming hotspot, the "enhanced" self-luminescence facilitated by the win-win cooperation of the aggregation-induced emission and self-luminescent techniques has become a powerful tool for interdisciplinary research. This tutorial review summarizes the advancements of AIE-assisted self-luminescence including chemiluminescence and afterglow imaging, starting from the discussion on the design and working principles, luminescent mechanisms of self-luminescence fuels, versatile integrated approaches and advantages, and a broad range of representative examples in biosensors and oncotherapy. Finally, the current challenges and perspectives are discussed to further actuate the development of "enhanced" self-luminescence agents for biomedical diagnosis and treatment.
ISSN: 0306-0012
DOI: 10.1039/d2cs00228k
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2022 The Royal Society of Chemistry. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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