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Title: Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults
Authors: Lu, Yanxia
Lim, Wee Shiong
Jin, Xia
Nyunt, Ma Schwe Zin
Fulop, Tamas
Gao, Qi
Lim, Su Chi
Larbi, Anis
Ng, Tze Pin
Keywords: Science::Medicine
Issue Date: 2022
Source: Lu, Y., Lim, W. S., Jin, X., Nyunt, M. S. Z., Fulop, T., Gao, Q., Lim, S. C., Larbi, A. & Ng, T. P. (2022). Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults. Frontiers in Medicine, 9, 971622-.
Project: NMRC/1108/2007
Journal: Frontiers in Medicine
Abstract: Background: Sarcopenia is common among older individuals with and without type 2 diabetes mellitus (T2DM). There are conflicting evidence in support of the role of insulin in the development of age-related and T2DM-related sarcopenia. We investigated the relationships between the levels of fasting insulin and other blood biomarkers related to insulin or lipid metabolism with the presence of sarcopenia in two independent studies. Materials and methods: In 246 pre-frail frail older individuals with (n = 41) and without T2DM (n = 205) in the Singapore Frailty Interventional Trial, sarcopenia was defined by low appendicular lean mass (ALM) relative to total body mass (skeletal muscle index, SMI = ALM/height2) and low lower limb strength or gait speed according to the Asian Working Group for Sarcopenia (AWGS) criteria released in 2019, and related to levels of fasting insulin and glucose, C-peptide, IGF-1, leptin, and active ghrelin. This investigation was validated in another independent study sample of 189 robust and pre-frail frail elderly in the Singapore Longitudinal Aging Study Wave 2 (SLAS-2). Results: Compared to non-sarcopenic individuals, those with sarcopenia and possible sarcopenia showed significantly lower fasting insulin (p < 0.05) in pre-frail/frail and non-frail older individuals. Consistent trends of relationships were observed for serum levels of C-peptide, IGF-1, leptin, and active ghrelin. In multivariable logistic regression models, sarcopenia was independently associated with low insulin (p < 0.05). Levels of fasting insulin, C-peptide, and leptin were also significantly associated with BMI, SMI, knee extension strength, gait speed, and physical activity score. Conclusion: Dysregulated insulin secretion in diabetic and non-diabetic older individuals may play an important role in age-related and diabetes-related sarcopenia.
ISSN: 2296-858X
DOI: 10.3389/fmed.2022.971622
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Tan Tock Seng Hospital
Rights: © 2022 Lu, Lim, Jin, Zin Nyunt, Fulop, Gao, Lim, Larbi and Ng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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